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Integrins in health and disease : key effectors of cell-matrix and cell-cell interactions / Donald Gullberg, Johannes A. Eble, editors.

Gullberg, Donald E., editor.; Eble, Johannes A., 1964- editor.
2023
QP552.I55
Available Online
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Title
Integrins in health and disease : key effectors of cell-matrix and cell-cell interactions / Donald Gullberg, Johannes A. Eble, editors.
ISBN
9783031237812 (electronic bk.)
3031237811 (electronic bk.)
9783031237805
3031237803
DOI
https://doi.org/10.1007/978-3-031-23781-2
Published
Cham : Springer, [2023]
Copyright
©2023
Language
English
Description
1 online resource (xii, 472 pages) : illustrations.
Item Number
10.1007/978-3-031-23781-2 doi
Call Number
QP552.I55
Dewey Decimal Classification
572/.68
Summary
Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
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Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Gullberg, Donald E., editor.
Eble, Johannes A., 1964- editor.
Series
Biology of extracellular matrix ; v. 13.
Available in Other Form
Integrins in health and disease.
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Part 1: Knockouts and animal models
Integrins 11 and 21 The generalist collagen receptors
Roles for Integrin 31 in Development and Disease
Part 2: Fibrosis& Cancer
Integrins: Key targets in tissue fibrosis and tumor stroma
Integrins in Cardiac Form, Function and Disease
Integrin 8 and its ligand nephronectin in health and disease
v integrin-dependent TGF activation in cancer: a brief update
Part 3: Human disease
a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis
Integrins in pathological tissue remodelling of joints
4 integrins in immune homeostasis and disease
2-integrins in immunity: new roles for old players
Structure and function of the leukocyte integrin M2
Part 4: Integrins in hemostasis, and immune control
Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation
Integrins as receptors for bacterial and viral pathogens.

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