Intro
Preface
Volume 1: MDDS
Volume 2: TDDS
Volume 3: VDDS
Volume 4: IDDS
Contents
Global Health and Tuberculosis
Past, Present, and Future
1 What Is Tuberculosis
2 The History of the Outbreak
3 Treatments over the Time
4 Tuberculosis: World Scenario
4.1 Africa
4.2 Western Pacific/East Asia
4.3 Southern Asia
4.4 The Middle East
5 Conclusion and Future Trends
References
Tuberculosis: Cellular Understanding of Disease
1 Introduction
2 Mtb Complex
3 Initial Transmission of Mtb
4 Mechanism of Mtb-Host Interaction

4.1 Phagocytosis and Immune Cells
4.2 Inhibition of Phagolysosome Maturation
4.3 Inhibition of Phagolysosome Acidification
4.4 Inhibition of Ubiquitination
5 Classification of Tuberculosis
5.1 Pulmonary and Extrapulmonary TB
5.1.1 Pulmonary TB
5.1.2 Extrapulmonary TB
Miliary
Spine (Pott's disease)
Lymphatic (Tuberculous Lymphadenitis)
6 Organizations Involved in TB Research
7 Conclusion
References
Metal Nanoparticles in Tuberculosis
1 Introduction
2 Pathogenesis and Immunology of TB
3 Role of Macrophages

3.1 Primary Phagosome-Lysosome Fusion Prevention
3.2 Escape of M.tb into the Cytosol
3.3 Non-phagocytic Internalization of M.tb in Macrophages
4 Interaction of Metal Nanoparticles and Macrophages
5 Diagnostic Applications
5.1 Noble Metal Nanoparticles and Metal Oxide Nanoparticles-Based Diagnostics
6 Metal Nanoparticles for Targeted Treatment
7 Toxicity Aspect of Metal Nanoparticles
8 Conclusion and Future Prospective
References
Tuberculosis: Current Treatment Options and Future Scope
1 Introduction
2 Current Treatment and Drug Regimen

3 Challenges in Treatment of Tuberculosis
4 Recent Advancements in Treatment of Tuberculosis
4.1 Pharmaceutical Formulations
4.2 New Drugs or New Chemical Entities
4.3 Herbal Drugs
4.4 Recent Trials of New TB Drugs and Regimens
4.5 Vaccines
4.6 Others
5 Conclusions
References
Polymeric Nanoparticles in Tuberculosis
1 Introduction
2 Pathogenesis of Tuberculosis
3 Conventional Treatment and Its Limitation
4 Polymeric Nanoparticles
5 Polymer Used
5.1 Polysaccharide-Based Polymers
5.1.1 Chitosan Nanoparticles
5.1.2 Alginate Nanoparticles

5.1.3 Guar Gum Nanoparticles
5.2 Polypeptide and Protein-Based Polymers
5.2.1 Gelatin-Based Polymers
5.2.2 Albumin-Based Polymers
5.3 Other Synthetic Polymers
5.3.1 PLGA Nanoparticles
6 Conclusion
References
Solid Lipid Nanoparticles in Tuberculosis
1 Introduction
2 Nanotechnology in TB
3 Solid Lipid Nanoparticle
3.1 Composition of SLN
3.2 Method of Preparation of SLN
3.2.1 High-Pressure Homogenization (HPH)
3.2.2 Phase Inversion Temperature (PIT) Method
3.2.3 Microemulsion Dilution
3.2.4 Coacervation Method