5.1.2.4 Challenges and Concerns in Therapeutic Nucleic Acids/Gene Therapy
5.2 Conclusion and Prospects
References
Chapter 6: Coupling Glucose Phosphorylation to Oxygen in Brain Mitochondria: Would It Be a Redox Set Point
6.1 Introduction
6.1.1 Glucose and Oxygen Fluxes in Brain, ROS and Dependence to Mitochondrial [delta]p
6.1.2 Controlling the Flow Mixture of Glucose and Oxygen in Brain. Do Mitochondria Play a Role
6.1.3 Glucose Phosphorylation at Mitochondria in Mammalian Cells by Hexokinase. Or Why Otto Meyerhof Failed to Activate Glucos...

Intro
Preface
Contents
About the Editors
Chapter 1: Cardioimmunology: An Interdisciplinary Approach
1.1 The Heart
1.2 Immune System and Cardiovascular Diseases
1.2.1 Inflammation and Heart
1.2.1.1 Innate Response
1.2.1.2 Adaptive Response
1.2.1.3 Adaptative-Innate Immune Response Crosstalk and Heart
1.3 Biotechnological Tools Applied to the Treatment of Cardiovascular Diseases: New Insights
1.4 Final Considerations
References
Chapter 2: Vascular Inflammation: From Cellular Mechanisms to Biotechnology Advances
2.1 Introduction

2.2 Blood Vessels and Vascular Inflammation
2.3 Cellular Markers of Vascular Inflammation
2.4 Chemical Markers of Vascular Inflammation
2.5 Molecular Markers of Vascular Inflammation
2.6 Biotechnology Advances in Diagnosis and Therapies for Vascular Inflammation
2.7 Conclusion and Prospects
References
Chapter 3: Methods for the Analysis of Arachidonic Acid-Derived Metabolites in Platelets
3.1 Introduction
3.2 AA Metabolism in Platelets: COX and LOX
3.3 Analytical Techniques to Detect and Quantify Bioactive Lipids in Platelets
3.3.1 HPLC with Ultraviolet Detection

3.3.2 HPLC with Fluorimetric Detection
3.3.3 MS Analysis of AA-Derived Metabolites
3.4 Analysis of Arachidonic Acid-Derived Metabolites on Platelet Mitochondria
3.5 Concluding Remarks
References
Chapter 4: Cancer Therapy-Induced Inflammation and Its Consequences
4.1 How Cancer Therapy Induces Inflammation?
4.1.1 The Role of Cell Death
4.1.2 How Cell Death Signals in Inflammation and Immunity?
4.1.3 Cytokines, Driving Mediators of Dying Cell-Induced Inflammatory Response
4.2 Beyond Cytokines. The Role of Lipid Mediators Produced by Cancer Therapy

4.2.1 Prostaglandin E2 (PGE2)
4.2.2 Platelet Activating Factor (PAF)
4.2.3 Resolvins
4.3 Modulating Inflammation for Cancer Therapy by Nanobiotechnology
4.4 Conclusion and Prospects
References
Chapter 5: Advanced Therapies for Patients with COVID-19
5.1 Introduction
5.1.1 Mesenchymal Stromal Cell Therapy for COVID-19
5.1.1.1 Use of MSCs to Treat Other Viral Infections
5.1.1.2 Rationale for Use of MSCs in COVID-19
5.1.2 Therapeutic Nucleic Acids/Gene Therapy
5.1.2.1 CRISPR-Cas System
5.1.2.2 Antisense Oligonucleotides
5.1.2.3 mRNA-Based Vaccines