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001461656 001__ 1461656
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001461656 0247_ $$a10.1007/978-981-19-7376-5$$2doi
001461656 035__ $$aSP(OCoLC)1373985870
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001461656 049__ $$aISEA
001461656 050_4 $$aQR171.G29
001461656 08204 $$a612.3/2$$223/eng/20230327
001461656 24500 $$aNeuroinflammation, gut-brain axis and immunity in neuropsychiatric disorders /$$cYong-Ku Kim, editor.
001461656 260__ $$aSingapore :$$bSpringer,$$c2023.
001461656 300__ $$a1 online resource (xvii, 564 pages) :$$billustrations (chiefly color).
001461656 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 1411
001461656 500__ $$a6.3.1 Observational Human Studies
001461656 5050_ $$aIntro -- Preface -- Contents -- Contributors -- Part I: Rethinking and Paradigm Shift -- 1: Neuron-Microglia Crosstalk in Neuropsychiatric Disorders -- 1.1 Introduction -- 1.2 Physiological Roles of Microglia -- 1.3 Neuron-Microglia Crosstalk in Depression -- 1.4 Neuron-Microglia Crosstalk in Schizophrenia -- 1.5 Neuron-Microglia Crosstalk in Neurocognitive Disorder -- 1.6 Conclusions -- References -- 2: Microbiota-Gut-Brain Axis: Pathophysiological Mechanism in Neuropsychiatric Disorders -- 2.1 Introduction -- 2.2 Microbiota-Gut-Brain Axis
001461656 5058_ $$a2.3 Potential Communication Pathways Between Gut Microbiota and the Brain -- 2.3.1 Immunological Pathway -- 2.3.2 Microbial Metabolites -- 2.3.3 Endocrine System -- 2.3.4 Autonomic Nervous System -- 2.4 The Role of Gut-Microbiota-Brain Axis in Neuropsychiatric Illnesses -- 2.4.1 Autism Spectrum Disorder -- 2.4.2 Schizophrenia -- 2.4.3 Depression -- 2.4.4 Alzheimerś Disease -- 2.4.5 Parkinsonś Disease -- 2.5 Modulation of Gut Microbiota for the Treatment of Neuropsychiatric Disorders -- 2.6 Conclusions -- References
001461656 5058_ $$a3: Inflammation-Mediated Responses in the Development of Neurodegenerative Diseases -- 3.1 Introduction -- 3.2 Hallmarks of Neurodegenerative Diseases -- 3.3 The Role of Inflammation in the Development of Neurodegeneration -- 3.4 The Role of Neuroinflammation in the Pathogenesis of Neurodegenerative Diseases -- 3.4.1 Alzheimerś Disease -- 3.4.2 Parkinsonś Disease -- 3.4.3 Amyotrophic Lateral Sclerosis -- 3.4.4 Multiple Sclerosis -- 3.5 Model Systems Available to Study Inflammatory-Mediated Neurodegenerative Diseases -- 3.5.1 Alzheimerś Disease -- 3.5.2 Parkinsonś Disease
001461656 5058_ $$a3.5.3 Amyotrophic Lateral Sclerosis -- 3.6 Concluding Remarks and Future Directions -- References -- 4: Microbiome-Induced Autoimmunity and Novel Therapeutic Intervention -- 4.1 Introduction -- 4.2 Microbiome-Induced Autoimmunity -- 4.2.1 Microbiome -- 4.2.2 Maternal Microbiota -- 4.2.3 Hygiene Hypothesis -- 4.2.4 Epithelial Barrier Hypothesis and Leaky Gut Syndrome (LGS) -- 4.2.5 Dysbiosis -- 4.2.6 The Role of B Cells -- 4.2.7 The Role of Toll-like Receptor (TLR) Ligands -- 4.2.8 Autoimmunity -- 4.3 Novel Therapeutic Intervention -- 4.3.1 Engineering the Gut Microbiota
001461656 5058_ $$a4.3.2 Personalized Nutrition -- 4.3.3 Probiotics and Prebiotics -- 4.3.4 Fecal Microbiota Transplantation (FMT) -- 4.3.5 Vaccination -- 4.4 Conclusion -- References -- 5: Animal Inflammation-Based Models of Neuropsychiatric Disorders -- 5.1 Introduction -- 5.2 Animal Models of Inflammation and CNS Disorders -- 5.3 Zebrafish Models -- 5.4 Conclusion -- References -- 6: Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood -- 6.1 Introduction -- 6.2 Early Life Stress and Inflammation -- 6.2.1 Experimental Animal Studies -- 6.3 Early Life Stress and Inflammation
001461656 506__ $$aAccess limited to authorized users.
001461656 520__ $$aThis book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
001461656 588__ $$aDescription based on print version record.
001461656 650_0 $$aGastrointestinal system$$xMicrobiology.
001461656 650_0 $$aNervous system$$xDiseases$$xMicrobiology.
001461656 655_0 $$aElectronic books.
001461656 7001_ $$aKim, Yong-Ku,$$eeditor.
001461656 77608 $$iPrint version:$$aKim, Yong-Ku$$tNeuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders$$dSingapore : Springer Singapore Pte. Limited,c2023$$z9789811973758
001461656 830_0 $$aAdvances in experimental medicine and biology ;$$v1411.
001461656 852__ $$bebk
001461656 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-19-7376-5$$zOnline Access$$91397441.1
001461656 909CO $$ooai:library.usi.edu:1461656$$pGLOBAL_SET
001461656 980__ $$aBIB
001461656 980__ $$aEBOOK
001461656 982__ $$aEbook
001461656 983__ $$aOnline
001461656 994__ $$a92$$bISE