Intro
Contents
Part I: Clinical Features and Diagnosis
Introduction
1 Early History of the Diabetic Neuropathies
2 The Twentieth Century
References
The Epidemiology of Diabetic Neuropathy
1 Introduction
1.1 Strategy for Reviewing Relevant Literature
2 Diabetic Distal Symmetric Polyneuropathy
2.1 Issues to Consider When Evaluating Epidemiological Studies of DSPN
2.2 Prevalence of DSPN
2.3 Painful Diabetic Neuropathy
2.4 Incidence of DSPN
2.5 Risk Factors for DSPN and P-DSPN
2.6 DSPN Complications
3 Diabetic Autonomic Neuropathy

3.1 Cardiovascular Autonomic Neuropathy
3.2 Prevalence of CAN
3.2.1 Youth
3.2.2 Type 1 Diabetes
3.2.3 Type 2 diabetes
3.3 Incidence of CAN
3.4 Risk Factors for CAN
3.5 Other Forms of Autonomic Neuropathy
4 Other Forms of Diabetic Neuropathy
References
Clinical Features of Diabetes Neuropathies
1 Introduction
2 Epidemiology
3 Classification
4 Clinical Features of Diabetic Neuropathies
4.1 Diabetic Peripheral Neuropathy
4.1.1 Painful Diabetic Peripheral Neuropathy
4.1.2 Co-morbidities of Diabetic Peripheral Neuropathy

4.1.3 Differential Diagnosis of Diabetic Peripheral Neuropathy
4.2 Acute Painful-Distal Sensorimotor Polyneuropathies
4.2.1 Hyperglycaemia Induced Acute Painful Distal Sensorimotor Polyneuropathy
4.2.2 Treatment Induced Neuropathy of Diabetes
4.2.3 Autonomic Neuropathy
4.2.4 Cardiovascular Autonomic Neuropathy
4.2.5 Gastrointestinal Autonomic Neuropathy
4.2.6 Urogenital Autonomic Neuropathy
4.2.7 Sudomotor Dysfunction
4.3 Mononeuropathies
4.3.1 Microvasculitic Mononeuropathies
4.3.2 Entrapment Mononeuropathies
4.4 Radiculoplexus Neuropathies

5 Conclusions
References
Neuropathy in Type 1 and Type 2 Diabetes
1 Introduction
2 Clinical Features of DPN
3 Risk Factors for DPN
4 Clinical Trials in DPN
References
Clinical Diagnosis of Diabetic Peripheral Neuropathy
1 Introduction and Context
1.1 Diabetic Distal Symmetric Polyneuropathy (Diabetic DSP): A Brief Overview
1.2 Staging of Diabetic DSP
2 Key Clinical Considerations FOR Diabetic DSP Diagnosis
2.1 Clinical Risk Factors for Diabetic DSP Are Typically Present

2.2 The Impaired Protective Sensation of Diabetic DSP Represents Only One Component Cause of Foot Complications
2.3 Impaired Protective Sensation Shows Heterogeneity Between People with Diabetes
3 Asymptomatic Clinical Presentation: Screening for Diabetic DSP
4 Neuropathic Symptoms
5 Neuropathic Signs
6 Composite Symptom Scales, Sign Scales, and Combined Scales
7 The Michigan Neuropathy Screening Instrument (MNSI)
7.1 Scale Face Validity
7.2 Test Quality and Reliability
7.3 Diagnostic Accuracy: Concurrent
7.4 Diagnostic Accuracy: Predictive