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Hereditary gastric and breast cancer syndrome : CDH1 : one genotype with multiple phenotypes / Giovanni Corso, Paolo Veronesi, Franco Roviello, editors.
Corso, Giovanni (Writer on surgical sciences), editor.; Veronesi, Paolo (Surgeon), editor.; Roviello, Franco, editor.
2023
RC280.S8
Available Online

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Title Hereditary gastric and breast cancer syndrome : CDH1 : one genotype with multiple phenotypes / Giovanni Corso, Paolo Veronesi, Franco Roviello, editors.
ISBN 9783031213175 (electronic bk.)
3031213173 (electronic bk.)
9783031213168
3031213165
DOI https://doi.org/10.1007/978-3-031-21317-5
Published Cham : Springer, 2023.
Language English
Description 1 online resource (453 pages) : illustrations (black and white, and colour).
Other Standard Identifiers 10.1007/978-3-031-21317-5 doi
Call Number RC280.S8
Dewey Decimal Classification 616.99/4330426
Summary In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Corso, Giovanni (Writer on surgical sciences), editor.
Veronesi, Paolo (Surgeon), editor.
Roviello, Franco, editor.
Available in Other Form Hereditary gastric and breast cancer syndrome.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
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Part I. Epidemiology
Family History and the Risk of Breast and Gastric Cancer
Worldwide CDH1 Germline Mutation Frequency and the Transhormesis Hypothesis
Hereditary Lobular Breast Cancer: A Newly Defined Syndrome
Part II. Genetics
Genetic Counseling and Prevention in Families at High Risk for HDGC and Other Hereditary Syndromes
CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes
Revisiting the Biological and Clinical Impact of CDH1 Missense Variants
Other Syndromes and Genes Associated with Gastric Cancer Predisposition
Computer-Assisted Interpretation of Cancer-Predisposing Variants
Part III. Pathology
Histopathology of Hereditary Diffuse Gastric Cancer: From Grossing and 3D Microscopy to Immunophenotypic and Molecular Profiling
HER2 Testing in Breast and Gastric Cancer with CDH1 Germline Mutations
Pathology and Somatic Alterations in Hereditary Lobular Breast Cancers
Part IV. Endoscopy and Imaging
Endoscopy: Is there Anything New?
Endoscopic Surveillance and Pathology of Biopsies in CDH1, CTNNA1 and HDGC-Like Families
Lobular Carcinoma of the Breast: Spectrum of Imaging Findings and New Emerging Technologies on the Horizon
Part V. Surgery
Prophylactic Total Gastrectomy: Techniques
Prophylactic Total Gastrectomy: How Many?
Hereditary Lobular Breast Cancer Syndrome: Role of Surgery
Breast Reconstruction
Part VI. New Issues
Psychological Burden and Preferences in CDH1 Mutation Carriers: Beyond the Cancer Diagnosis
Drug Repurposing in Gastric Cancer: Current Status and Future Perspectives
The Chemoprevention of Hereditary Diffuse Gastric Cancer
Malformations and Malformative Syndromes Associated with CDH1
Hereditary Breast Cancer Non-CDH1 Associated
Part VII. Patient Advocacy
My Hereditary Gastric Cancer
Hereditary Breast Cancer Syndrome, My Experience
Part VIII. Miscellaneous
-Hemoglobinopathies and Early Onset of Cancers in Adulthood. Epidemiology in Southeastern Asia & Brunei with Emphasis for Prevention and Treatment.

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