Glycosignals in cancer : molecular assembly and recognition / Koichi Furukawa, Minoru Fukuda, editors.
Furukawa, Kōichi, Professor, editor.; Fukuda, Minoru, 1945- editor.
2023
RC268.4
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Title
Glycosignals in cancer : molecular assembly and recognition / Koichi Furukawa, Minoru Fukuda, editors.
Edition
Second edition.
ISBN
9789811977329 (electronic bk.)
9811977321 (electronic bk.)
9789811977312
9811977313
DOI
https://doi.org/10.1007/978-981-19-7732-9
Published
Singapore : Springer, 2023.
Language
English
Description
1 online resource (291 pages) : illustrations (black and white, and colour).
Item Number
10.1007/978-981-19-7732-9 doi
Call Number
RC268.4
Dewey Decimal Classification
616.994
Summary
This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
Access Note
Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Furukawa, Kōichi, Professor, editor.
Fukuda, Minoru, 1945- editor.
Available in Other Form
Glycosignals in cancer.
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Part I. Search for novel tumor epitopes related to carbohydrates
Chapter 1.1. The ganglioside structures: chemistry and biochemistry
Chapter 1.2. Fucosylated proteins as cancer biomarkers
Part II. Assembly of glycoconjugates
Chapter 2.1. Siglec-7 and synthetic sialylpolymer
Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis
Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer
Part III. Signaling pathways modulated by glycosylation
Chapter 3.1. Significance of FUT8in pancreatic cancer and others
Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells
Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules
Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells
Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction
Part V. Clinical trials targeting glycosignals
Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.

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