TY  - GEN
AB  - Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a lead compound) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
AU  - Robinson, Brian,
CN  - RS165.C16
DO  - 10.1007/978-94-024-1191-1
DO  - doi
ID  - 1461872
KW  - Calabar bean
KW  - Calabar bean
KW  - Materia medica, Vegetable.
KW  - Botanical chemistry.
KW  - Phytothérapie.
KW  - Chimie végétale.
LK  - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-94-024-1191-1
N2  - Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a lead compound) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
SN  - 9789402411911
SN  - 9402411917
T1  - The Calabar bean and its alkaloids :from magic, via miracle, to memory /
TI  - The Calabar bean and its alkaloids :from magic, via miracle, to memory /
UR  - https://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-94-024-1191-1
ER  -