The Calabar bean and its alkaloids : from magic, via miracle, to memory / Brian Robinson.

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The Calabar bean and its alkaloids : from magic, via miracle, to memory / Brian Robinson.

9789402411911 (electronic bk.)
9402411917 (electronic bk.)
9789402411904
9402411909

Dordrecht : Springer, [2023]

©2023

English

1 online resource (xxvi, 267 pages) : illustrations

10.1007/978-94-024-1191-1 doi

RS165.C16

615.3/21

Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a lead compound) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.

Includes bibliographical references and index.

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