The Calabar bean and its alkaloids : from magic, via miracle, to memory / Brian Robinson.
Robinson, Brian, author.
2023
RS165.C16
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Title
The Calabar bean and its alkaloids : from magic, via miracle, to memory / Brian Robinson.
Author
Robinson, Brian, author.
ISBN
9789402411911 (electronic bk.)
9402411917 (electronic bk.)
9789402411904
9402411909
DOI
https://doi.org/10.1007/978-94-024-1191-1
Published
Dordrecht : Springer, [2023]
Copyright
©2023
Language
English
Description
1 online resource (xxvi, 267 pages) : illustrations
Item Number
10.1007/978-94-024-1191-1 doi
Call Number
RS165.C16
Dewey Decimal Classification
615.3/21
Summary
Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a lead compound) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
Bibliography, etc. Note
Includes bibliographical references and index.
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Access limited to authorized users.
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Description based on print version record.
Available in Other Form
Calabar bean and its alkaloids.
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Chronology
Abbreviations
Preface and acknowledgements
1. Introduction
2. l-Physostigmine (eserine)
3. l-Physovenine
4. l-Eseramine
5. l-N(8)-Norphysostigmine
6. l-Geneserine
7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean
8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean
9. Non-alkaloidal components of the Calabar bean
10. Biological activities of the alkaloids of the Calabar bean
11. Notes
12. References
13. Index.

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