Cholesterol and PI(4,5)P2 in vital biological functions : from coexistance to crosstalk / Avia Rosenhouse-Dantsker, editor.
Rosenhouse-Dantsker, Avia, editor.
2023
QP752.C5
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Title
Cholesterol and PI(4,5)P2 in vital biological functions : from coexistance to crosstalk / Avia Rosenhouse-Dantsker, editor.
ISBN
9783031215476 (electronic bk.)
3031215478 (electronic bk.)
303121546X
9783031215469
DOI
https://doi.org/10.1007/978-3-031-21547-6
Publication Details
Cham : Springer, 2023.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-031-21547-6 doi
Call Number
QP752.C5
Dewey Decimal Classification
572/.5795
Summary
Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each others levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes. This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI(4,5)P2 functions extend from parallel existence to crosstalk. It includes four sections. The first section introduces the reader to cholesterol and PI(4,5)P2. The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer proteins. The fourth section highlights other cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement. Collectively, the book portrays the emerging relationship between cholesterol and PI(4,5)P2 in a broad array of biological systems and processes. The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems, as well as graduate students, postdoctoral trainees, basic and clinical researchers, and pharmaceutical scientists. Specifically, the content will be relevant to researchers in the fields of biochemistry, molecular biophysics, pharmacology, neurobiology, cardiovascular biology, among others.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed April 6, 2023).
Added Author
Rosenhouse-Dantsker, Avia, editor.
Series
Advances in experimental medicine and biology ; v. 1422. 2214-8019
Available in Other Form
Print version: 9783031215469
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Preface
1. Mutual influence of cholesterol and PI(4,5)P2 on their levels
Chapter 1. Mechanism of the regulation of plasma cholesterol levels by PI(4,5)P2
Chapter 2. Effect of cholesterol depletion on ciliary PI(4,5)P2 levels
Chapter 3. Impact of cholesterol on PI(4,5)P2 levels in the brain
Chapter 4. Alterations in PIP2 levels in the intracellular cholesterol trafficking disorder NPC1
Chapter 5. Targeting cholesterol release and PI(4,5)P2 redistribution by the oral drug Miltefosine
2. Cross-talk between cholesterol and PI(4,5)P2 as a factor affecting protein function
A. Plasma membrane ion channels
Chapter 6. From cross-talk to synergism: the combined effect of cholesterol and PI(4,5)P2 on inwardly rectifying potassium channels
Chapter 7. Link between lysosomal cholesterol and PI(4,5)P2 in the regulation of the voltage gated KCNQ2/3 potassium channel
Chapter 8. Cholesterol and PI(4,5)P2 binding to a ciliary membrane transient receptor potential channel
Chapter 9. Regulation of ell by cholesterol and PI(4,5)P2
Chapter 10. Cholesterol stimulates the epithelial sodium channel in a PI(4,5)P2-dependent manner
Chapter 11. Roles of cholesterol and PI(4,5)P2 in store operated calcium entry
Chapter 12. Roles of cholesterol and PI(4,5)P2 levels in the modulation of the calcium activated chloride channel TMEM16A
B. Lipid transport proteins
Chapter 13. PI(4,5)P2 facilitates ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction
Chapter 14. Role of PI(4,5)P2 binding in ORP2-mediated cholesterol distribution
Chapter 15. PI(4,5)P2-dependent transport of cholesterol from lysosomes to peroxisomes at lysosomeperoxisome contact sites
3. Cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement
Chapter 16. The insertion of the N-terminal domain of Gasdermin-D is increased by PI(4,5)P2 and decreased by cholesterol
Chapter 17. Cholesterol promotes the cooperative interaction of formins with PI(4,5)P2 to initiate actin nucleation
Chapter 18. Cooperation between cholesterol and PI(4,5)P2 in the regulation of Engrailed-2 homeoprotein intercellular trafficking
Chapter 19. Cholesterol and PI(4,5)P2 as a membrane nanoplatform for HIV assembly
Chapter 20. Role of Cholesterol and PI(4,5)P2 in the localization of the HIV-1 structural polyprotein Gag to the plasma membrane.

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