001462085 000__ 04716cam\a22006137i\4500 001462085 001__ 1462085 001462085 003__ OCoLC 001462085 005__ 20230503003425.0 001462085 006__ m\\\\\o\\d\\\\\\\\ 001462085 007__ cr\cn\nnnunnun 001462085 008__ 230412s2023\\\\sz\a\\\\ob\\\\001\0\eng\d 001462085 019__ $$a1375438967 001462085 020__ $$a9783031232053$$q(electronic bk.) 001462085 020__ $$a3031232054$$q(electronic bk.) 001462085 020__ $$z9783031232039 001462085 020__ $$z3031232038 001462085 0247_ $$a10.1007/978-3-031-23205-3$$2doi 001462085 035__ $$aSP(OCoLC)1375575148 001462085 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDX 001462085 049__ $$aISEA 001462085 050_4 $$aRM852 001462085 08204 $$a616.07/575$$223/eng/20230412 001462085 1001_ $$aVallabhajosula, Shankar,$$eauthor.$$1https://isni.org/isni/0000000071499778 001462085 24510 $$aMolecular imaging and targeted therapy :$$bradiopharmaceuticals and clinical applications /$$cShankar Vallabhajosula. 001462085 250__ $$aSecond edition. 001462085 264_1 $$aCham :$$bSpringer,$$c2023. 001462085 300__ $$a1 online resource (800 pages) :$$billustrations (black and white, and color). 001462085 336__ $$atext$$btxt$$2rdacontent 001462085 337__ $$acomputer$$bc$$2rdamedia 001462085 338__ $$aonline resource$$bcr$$2rdacarrier 001462085 504__ $$aIncludes bibliographical references and index. 001462085 5050_ $$aMolecular Imaging and Targeted Therapy: Introduction -- Atomism and Radioactivity: A Brief History -- Atoms and Radiation -- Radioactivity -- Production of Radionuclides -- PET and SPECT Scanners -- Chemistry: Basic Principles -- Cell and Molecular Biology -- Radiopharmaceuticals -- Chemistry of Organic Radionuclides (C, N, and O) -- Chemistry of Radiohalogens (F, Br, I, and At) -- Chemistry of Trivalent Metals Radionuclides (Ga, In, Y, Lu) -- Chemistry of Transition Metals (Cu, Zr, Tc, Re) -- Quality Control of Radiopharmaceuticals -- Pharmacokinetics and Modeling -- Molecular Imaging in Oncology -- Molecular Imaging in Neurology and Psychiatry -- Molecular Imaging in Cardiology -- Molecular Imaging of Gene Expression and Cell Trafficking -- Radiation Dosimetry and Protection -- Radiopharmaceuticals for Targeted Therapy -- Targeted Therapy with Beta Emitting Radiopharmaceuticals -- Targeted Therapy with Alpha Emitting Radiopharmaceuticals -- Theranostics: Molecular Imaging and Targeted Therapy -- Radiopharmaceuticals: Drug Development and Regulatory Issues. 001462085 506__ $$aAccess limited to authorized users. 001462085 520__ $$aThis book, now published in its second edition, covers a wide range of topics relating to the use of radiopharmaceuticals. The basics of nuclear chemistry, radiochemistry, and radiopharmacology are considered in detail, regulatory issues are reviewed, and potential applications in drug development, translational medicine, clinical diagnostics, and targeted therapy are discussed. Compared with the first edition, the chapters on targeted therapy with alpha- and beta-emitting radiopharmaceuticals and theranostics are completely new. Other chapters have been updated and revised as necessary. Radioisotope-based molecular imaging probes (radiopharmaceuticals) provide unprecedented insights into biochemistry and function in both normal and diseased states of living systems, with unbiased in vivo measurements of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology, including functional magnetic resonance imaging, can provide such high sensitivity and specificity at a tracer level. This book, written by an experienced radiochemist and scientist, offers valuable insights into the full range of applications of this technology. 001462085 588__ $$aDescription based on print version record. 001462085 650_0 $$aRadiopharmaceuticals. 001462085 650_0 $$aTomography, Emission. 001462085 650_0 $$aSingle-photon emission computed tomography. 001462085 655_0 $$aElectronic books. 001462085 77608 $$iPrint version:$$aVallabhajosula, Shankar.$$tMolecular imaging and targeted therapy.$$bSecond edition.$$dCham : Springer, 2023$$z9783031232039$$w(OCoLC)1359610258 001462085 852__ $$bebk 001462085 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-23205-3$$zOnline Access$$91397441.1 001462085 909CO $$ooai:library.usi.edu:1462085$$pGLOBAL_SET 001462085 980__ $$aBIB 001462085 980__ $$aEBOOK 001462085 982__ $$aEbook 001462085 983__ $$aOnline 001462085 994__ $$a92$$bISE