Spray drying of vaccines : from laboratory research to industrial applications / Cordin Arpagaus.
Arpagaus, Cordin, author.
2023
TP248.65.V32 A77 2023
Available Online

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Title Spray drying of vaccines : from laboratory research to industrial applications / Cordin Arpagaus.
Author Arpagaus, Cordin, author.
ISBN 9783031243233 electronic book
3031243234 electronic book
3031243226
9783031243226
DOI https://doi.org/10.1007/978-3-031-24323-3
Published Cham, Switzerland : Springer, [2023]
Language English
Description 1 online resource (406 pages) : illustrations (black and white, and color).
Item Number 10.1007/978-3-031-24323-3 doi
Call Number TP248.65.V32 A77 2023
Dewey Decimal Classification 615.3/72
Summary This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from digital title page (viewed on May 09, 2023).
Available in Other Form SPRAY DRYING OF VACCINES.
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Chapter 1 A short introduction to vaccines
Chapter 2 Thermostability of vaccines
Chapter 3 Drying technologies for vaccines
Chapter 4 Aseptic spray drying technology
Chapter 5 Design of experiment studies and scale-up
Chapter 6 Applications of spray dried vaccines.-Chapter 7 Conclusions and future perspectives of spray-dried vaccines.

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