Molecular medicine : how science works / Carsten Carlberg, Eunike Velleuer, Ferdinand Molnár.
Carlberg, Carsten, author.; Velleuer, Eunike, author.; Molnár, Ferdinand, author.
2023
QH506 .C37 2023
Available Online

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Title Molecular medicine : how science works / Carsten Carlberg, Eunike Velleuer, Ferdinand Molnár.
Author Carlberg, Carsten, author.
ISBN 9783031271335 (electronic bk.)
3031271335 (electronic bk.)
9783031271328
3031271327
DOI https://doi.org/10.1007/978-3-031-27133-5
Published Cham : Springer, [2023]
Language English
Description 1 online resource (xxxiv, 700 pages) : illustrations (some color)
Other Standard Identifiers 10.1007/978-3-031-27133-5 doi
Call Number QH506 .C37 2023
Dewey Decimal Classification 572.8
Summary \The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed April 24, 2023).
Added Author Velleuer, Eunike, author.
Molnár, Ferdinand, author.
Available in Other Form Print version: 9783031271328
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1. The human genome and its variations
2. Gene expression and chromatin
3. The basal transcriptional machinery
4. Transcription factors and signal transduction
5. A key transcription factor family: Nuclear receptors
6. DNA methylation
7. Histone modifications
8. Chromatin remodeling and organization
9. Regulatory impact of non-coding RNA
10. Genome-wide principles of gene regulation
11. Epigenetics in development
12. Epigenetics and aging
13. Epigenetics and disease
14. Cells and tissues of the immune system
15. Innate immunity and inflammation
16. Adaptive immunity and antigen receptor diversity
17. B cell immunity: BCRs, antibodies and their effector functions
18. Antigen-presenting cells and MHCs
19. T cell immunity: TCRs and their effector functions
20. Immunity to bacterial pathogens and the microbiome
21. Immunity to viral pathogens and the virome
22. Tolerance and transplantation immunology
23. Immunological hypersensitivities: Allergy and autoimmunity
24. Introduction to cancer
25. Oncogenes, signal transduction and the hallmarks of cancer
26 Tumor suppressor genes and cell fate control
27. Multistep tumorigenesis and genome instability
28. Cancer genomics
29. Cancer epigenomics.-30. Aging and cancer
31. Tumor microenvironment
32 Metastasis and cachexia
33. Cancer immunology
34 Architecture of cancer therapies
35 Nutrition and common diseases
36 Interference of the human genome with nutrients
37. Nutritional epigenetics, signaling and aging
38. Chronic inflammation and metabolic stress
39. Obesity
40. Insulin resistance and diabetes
41. Heart disease and the metabolic syndrome
42 Epigenetics, inflammation and disease.

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