001463433 000__ 05443cam\a2200613\i\4500
001463433 001__ 1463433
001463433 003__ OCoLC
001463433 005__ 20230601003320.0
001463433 006__ m\\\\\o\\d\\\\\\\\
001463433 007__ cr\un\nnnunnun
001463433 008__ 230425s2023\\\\sz\a\\\\ob\\\\000\0\eng\d
001463433 019__ $$a1376739453
001463433 020__ $$a9783031271335$$q(electronic bk.)
001463433 020__ $$a3031271335$$q(electronic bk.)
001463433 020__ $$z9783031271328
001463433 020__ $$z3031271327
001463433 0247_ $$a10.1007/978-3-031-27133-5$$2doi
001463433 035__ $$aSP(OCoLC)1377291968
001463433 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDX$$dEBLCP$$dYDX
001463433 049__ $$aISEA
001463433 050_4 $$aQH506$$b.C37 2023
001463433 08204 $$a572.8$$223/eng/20230425
001463433 1001_ $$aCarlberg, Carsten,$$eauthor.$$1https://orcid.org/0000-0003-2633-0684
001463433 24510 $$aMolecular medicine :$$bhow science works /$$cCarsten Carlberg, Eunike Velleuer, Ferdinand Molnár.
001463433 264_1 $$aCham :$$bSpringer,$$c[2023]
001463433 300__ $$a1 online resource (xxxiv, 700 pages) :$$billustrations (some color)
001463433 336__ $$atext$$btxt$$2rdacontent
001463433 337__ $$acomputer$$bc$$2rdamedia
001463433 338__ $$aonline resource$$bcr$$2rdacarrier
001463433 504__ $$aIncludes bibliographical references.
001463433 5050_ $$a1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: Nuclear receptors -- 6. DNA methylation -- 7. Histone modifications -- 8. Chromatin remodeling and organization -- 9. Regulatory impact of non-coding RNA -- 10. Genome-wide principles of gene regulation -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and disease -- 14. Cells and tissues of the immune system -- 15. Innate immunity and inflammation -- 16. Adaptive immunity and antigen receptor diversity -- 17. B cell immunity: BCRs, antibodies and their effector functions -- 18. Antigen-presenting cells and MHCs -- 19. T cell immunity: TCRs and their effector functions -- 20. Immunity to bacterial pathogens and the microbiome -- 21. Immunity to viral pathogens and the virome -- 22. Tolerance and transplantation immunology -- 23. Immunological hypersensitivities: Allergy and autoimmunity -- 24. Introduction to cancer -- 25. Oncogenes, signal transduction and the hallmarks of cancer -- 26 Tumor suppressor genes and cell fate control -- 27. Multistep tumorigenesis and genome instability -- 28. Cancer genomics -- 29. Cancer epigenomics.-30. Aging and cancer -- 31. Tumor microenvironment -- 32 Metastasis and cachexia -- 33. Cancer immunology -- 34 Architecture of cancer therapies -- 35 Nutrition and common diseases -- 36 Interference of the human genome with nutrients -- 37. Nutritional epigenetics, signaling and aging -- 38. Chronic inflammation and metabolic stress -- 39. Obesity -- 40. Insulin resistance and diabetes -- 41. Heart disease and the metabolic syndrome -- 42 Epigenetics, inflammation and disease.
001463433 506__ $$aAccess limited to authorized users.
001463433 520__ $$a\The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research.
001463433 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed April 24, 2023).
001463433 650_0 $$aMolecular biology.
001463433 650_0 $$aHuman physiology.
001463433 655_0 $$aElectronic books.
001463433 7001_ $$aVelleuer, Eunike,$$eauthor.$$1https://orcid.org/0000-0003-4328-9556
001463433 7001_ $$aMolnár, Ferdinand,$$eauthor.$$1https://orcid.org/0000-0001-9008-4233
001463433 77608 $$iPrint version: $$z3031271327$$z9783031271328$$w(OCoLC)1365364042
001463433 852__ $$bebk
001463433 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-27133-5$$zOnline Access$$91397441.1
001463433 909CO $$ooai:library.usi.edu:1463433$$pGLOBAL_SET
001463433 980__ $$aBIB
001463433 980__ $$aEBOOK
001463433 982__ $$aEbook
001463433 983__ $$aOnline
001463433 994__ $$a92$$bISE