001463576 000__ 04443cam\a2200613\i\4500
001463576 001__ 1463576
001463576 003__ OCoLC
001463576 005__ 20230601003327.0
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001463576 019__ $$a1377620690
001463576 020__ $$a9783031290299$$q(electronic bk.)
001463576 020__ $$a3031290291$$q(electronic bk.)
001463576 020__ $$z3031290275
001463576 020__ $$z9783031290275
001463576 0247_ $$a10.1007/978-3-031-29029-9$$2doi
001463576 035__ $$aSP(OCoLC)1377816830
001463576 040__ $$aEBLCP$$beng$$erda$$cEBLCP$$dYDX$$dGW5XE$$dYDX
001463576 049__ $$aISEA
001463576 050_4 $$aQP552.T68$$bL52 2023
001463576 08204 $$a572.8/845$$223/eng/20230504
001463576 1001_ $$aLi, Willis X.,$$eauthor.
001463576 24514 $$aThe secret lives of transcription factors :$$bin heterochromatin regulation /$$cWillis X. Li, Louise Silver-Morse.
001463576 264_1 $$aCham :$$bSpringer,$$c[2023]
001463576 300__ $$a1 online resource (62 p.).
001463576 336__ $$atext$$btxt$$2rdacontent
001463576 337__ $$acomputer$$bc$$2rdamedia
001463576 338__ $$aonline resource$$bcr$$2rdacarrier
001463576 4901_ $$aSpringerBriefs in Biochemistry and Molecular Biology
001463576 504__ $$aIncludes bibliographical references and index.
001463576 5050_ $$aChapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.
001463576 506__ $$aAccess limited to authorized users.
001463576 520__ $$aThis SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
001463576 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed May 4, 2023).
001463576 650_0 $$aTranscription factors.
001463576 655_0 $$aElectronic books.
001463576 7001_ $$aSilver-Morse, Louise,$$eauthor.
001463576 77608 $$iPrint version:$$aLi, Willis X.$$tThe Secret Lives of Transcription Factors$$dCham : Springer International Publishing AG,c2023$$z9783031290275
001463576 830_0 $$aSpringerBriefs in biochemistry and molecular biology.
001463576 852__ $$bebk
001463576 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-29029-9$$zOnline Access$$91397441.1
001463576 909CO $$ooai:library.usi.edu:1463576$$pGLOBAL_SET
001463576 980__ $$aBIB
001463576 980__ $$aEBOOK
001463576 982__ $$aEbook
001463576 983__ $$aOnline
001463576 994__ $$a92$$bISE