The secret lives of transcription factors : in heterochromatin regulation / Willis X. Li, Louise Silver-Morse.
Li, Willis X., author.; Silver-Morse, Louise, author.
2023
QP552.T68 L52 2023
Available Online

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Title
The secret lives of transcription factors : in heterochromatin regulation / Willis X. Li, Louise Silver-Morse.
Author
Li, Willis X., author.
ISBN
9783031290299 (electronic bk.)
3031290291 (electronic bk.)
3031290275
9783031290275
DOI
https://doi.org/10.1007/978-3-031-29029-9
Published
Cham : Springer, [2023]
Language
English
Description
1 online resource (62 p.).
Item Number
10.1007/978-3-031-29029-9 doi
Call Number
QP552.T68 L52 2023
Dewey Decimal Classification
572.8/845
Summary
This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed May 4, 2023).
Added Author
Silver-Morse, Louise, author.
Series
SpringerBriefs in biochemistry and molecular biology.
Available in Other Form
The Secret Lives of Transcription Factors
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Online Access
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Chapter 1 Introduction
Chapter 2 Unconventional functions of transcription factors
GAGA transcription factor
Heterochromatin protein 1
Retinoblastoma protein
STAT
ATF-2
NF-kB
Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer
STAT and HP1 promote longevity
STAT and HP1 protect against DNA damage
Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model
Chapter 4 The possible biological significance of transcription factors unconventional functions
The epigenome
Processes in the cell nucleus
Future Work.

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