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Intro
Preface
Introduction of Chief Editor, Feilong Hei
The Main Academic Title
Scientific Research and Clinical Achievements
Introduction of Chief Editor, Yulong Guan
The Main Academic Title
Scientific Research and Clinical Achievements
Scientific Achievements
Scientific Training
Scientific Monographs
Scientific Papers
Introduction of Chief Editor, Kun Yu
The Main Academic Title
Scientific Research and Clinical Achievements
Contents
1: Physiology of Extracorporeal Life Support
Cardiovascular Physiology
Heart
Vasculature
Blood

Blood Composition
Transportation of O2 in Blood
Transportation of CO2 in Blood
Cardiovascular Pathophysiology
ECMO Circuit and Circuit Physiology
Blood Pumps
Roller Pumps
Rotary Pumps
Interaction Between Centrifugal Pump and Patient
Gas Exchange Device: Artificial Oxygenator
Blood Oxygenation in Oxygenator
CO2 Removal in Oxygenator
Other Functions of Oxygenator
Cannulas
Tubing and Connectors
Mechanism of Cardiorespiratory Support
Physiology of VA-ECMO
Hemodynamic Effects of VA-ECMO
Gas Exchange in VA-ECMO

Advantages and Disadvantages of VA-ECMO
Physiology of VV-ECMO
Hemodynamic Effects of VV-ECMO
Oxygenation in VV-ECMO
CO2 Removal in VV-ECMO
Recirculation During VV-ECMO
Advantages and Disadvantages of VV-ECMO
VA-ECMO vs. VV-ECMO
Pharmacokinetics During ECMO
Pumpless Extracorporeal Lung Assist (pECLA)
Summary
References
2: Equipment and Devices of Extracorporeal Life Support
Blood Pump
Centrifugal Pump Physics
Components of a Centrifugal Pump
Commercial Centrifugal Pumps
Membrane Oxygenator
Commercial Gas Exchange Devices
ECLS Tubing

General Principles of Circuit Design
Surface Coating Technology
Heat Exchanger/Heater-Cooler Device
Medicare Monitoring During ECLS
Hemoglobin Saturation Measurement
Anticoagulation Monitoring
Circuit Pressures
Colloid Osmotic Pressure
Plasma Free Hemoglobin
Temperature Monitoring
References
3: Types of Extracorporeal Life Support and Evolution of Extracorporeal Oxygenators
The Retrospective Glance on the Historical Development of ECLS/ECMO and Extracorporeal Oxygenators
Evolution of Extracorporeal Oxygenator and Its Use in Extracorporeal Life Support

Development of High-Performance Extracorporeal Oxygenators for ECMO Use-High Gas Exchange Efficiency, Low Flow Resistance, and Plasma Leak-Tight Oxygenator
Extracorporeal Membrane Oxygenation (ECMO)
Veno-Venous Extracorporeal Membrane Oxygenation (VV ECMO) Mode
VV Configurations and Cannulation Strategies
Special Consideration: Right Ventricular Failure During ARDS and VV ECMO
Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO) Mode
VA Configuration and Cannulation Strategies

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