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Title
Nucleic acid biology and its application in human diseases / Subhrangsu Chatterjee, Samit Chattopadhyay, editors.
ISBN
9789811985201 electronic book
9811985200 electronic book
9811985197
9789811985195
Published
Singapore : Springer, [2023]
Language
English
Description
1 online resource (xii, 416 pages) : illustrations (some color)
Other Standard Identifiers
10.1007/978-981-19-8520-1 doi
Call Number
RM666.N87 N83 2023
Dewey Decimal Classification
611/.01816
Summary
This book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from digital title page (viewed on May 16, 2023).
Chapter 1. Nucleic Acid Structure and biology
Chapter 2 . Nucleic acid-mediated inflammatory diseases
Chapter 3. Alternative splicing and cancer
Chapter 4. Nucleic acid-based strategies to treat neurodegenerative movement
Chapter 5. Human Diseases induced by Oxidative damage in DNA
Chapter 6. Nucleic Acid in Nanotechnology
Chapter 7. Nucleic Acid in Diagnostics
Chapter 8. Nucleic Acid sensors and logic gates
Chapter 9. Nucleic Acid Therapeutics in Cancer Biology
Chapter 10. RNA vaccines
Chapter 11. Nucleic Acid Editing.
