Nucleic acid biology and its application in human diseases / Subhrangsu Chatterjee, Samit Chattopadhyay, editors.

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Nucleic acid biology and its application in human diseases / Subhrangsu Chatterjee, Samit Chattopadhyay, editors.

9789811985201 electronic book
9811985200 electronic book
9811985197
9789811985195

Singapore : Springer, [2023]

English

1 online resource (xii, 416 pages) : illustrations (some color)

10.1007/978-981-19-8520-1 doi

RM666.N87 N83 2023

611/.01816

This book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy.

Includes bibliographical references.

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Description based on online resource; title from digital title page (viewed on May 16, 2023).

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