Cover
Contents
Acknowledgments
Abbreviations
Abstract
1 Introduction
1.1 Heart failure
1.1.1 Pathophysiology of HF
1.1.2 Integration of Cardiac and Vascular Changes
1.1.3 Compensatory mechanisms in HF
1.1.4 Clinical presentation
1.1.5 Therapy and prognosis
1.1.6 Acute management strategies
1.2 Heart failure models
1.3 ECLS
1.3.1 Definition of ECLS
1.3.2 History of ECLS
1.3.3 Indications and incidence of ECMO
1.3.4 Anatomy of ECMO
1.3.5 Pathophysiology of VA ECMO
1.3.6 Monitoring of ECMO circuit
1.3.7 Complications of ECMO
1.3.8 Hemodynamics of VA ECMO
2 Hypotheses
3 Aims
4 Methodology
4.1 Animal model of chronic heart failure
4.2 Animal model of acute HF induced by regionalcoronary hypoxemia
4.3 Animal model of acute HF induced by globalcoronary hypoxemia
4.4 Animal model of right-sided HF
4.5 Experimental preparation and hemodynamicmonitoring
4.6 Left ventricular parameters and stroke workanalysis
4.7 ECMO instrumentation
4.8 Experimental ECMO protocols and data acquisition
4.9 Statistical analysis
5 Results
5.1 Characteristics of developed chronic HF model
5.2 Characteristics of acute HF model induced byregional coronary hypoxemia
5.3 Characteristics of acute HF model induced byglobal coronary hypoxemia
5.4 Characteristics of right-sided HF model
5.5 Effects of EBF on chronic HF
5.6 Effects of EBF on acute HF
6 Discussion
6.1 Comments on HF animal models
6.2 EBF effects on chronic HF
6.3 EBF effects on acute HF
6.4 Correlation of tissue saturation and perfusion
6.5 Effects of flow pulsatility
6.6 Clinical considerations
6.7 Study limitations
7 Conclusions
8 List of linked documents
9 References.