Advances in pharmacokinetics and pharmacodynamics / Panos Macheras, editor.
Macheras, P. (Panos), editor.
2023
RM301.5
Available Online

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Title Advances in pharmacokinetics and pharmacodynamics / Panos Macheras, editor.
ISBN 9783031295416 (electronic bk.)
3031295412 (electronic bk.)
9783031295409
3031295404
DOI https://doi.org/10.1007/978-3-031-29541-6
Published Cham : Springer, 2023.
Language English
Description 1 online resource (xi, 204 pages) : illustrations (some color)
Other Standard Identifiers 10.1007/978-3-031-29541-6 doi
Call Number RM301.5
Dewey Decimal Classification 615.7
Summary This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed June 1, 2023).
Added Author Macheras, P. (Panos), editor.
Series AAPS introductions in the pharmaceutical sciences ; v. 9. 2522-8358
Available in Other Form Print version: 9783031295409
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Pharmacokinetics
Chapter 1: Current status in PBPK modeling
Chapter 2: Physiologically based biopharmaceutics modeling (PBBM) Application on Food Effect Assessment
Chapter 3: Physiologically based finite time pharmacokinetic (PBFTPK) models: Inception and development
Chapter 4: Physiologically based finite time pharmacokinetic (PBFTPK) models: Applications
Pharmacodynamics
Chapter 5: Pharmacokinetic – Pharmacodynamic Modelling and Simulation in Clinical Practice and Studies
Chapter 6: On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body
Chapter 7: Impact of Clinical Pharmacology on the Modernization of Drug Development and Regulation.

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