1. What are smart nanomaterials (SNM)? 1.1 Definitions for SNM 1.2 Synthesis methods 1.3 Characterization techniques 2. Why SNM play a significant role today? 2.1 Progress in SNM 2.2 Safe and sustainable innovations of nanomaterials 3. SNM for bio-medical applications 3.1 Nanoparticle based biosensors 3.2 Smart nanoparticles for photodynamic therapy 3.3 Smart nanoparticle for passive and active gene delivery 3.4 Magnetic nanoparticles and their applications in tissue engineering 4. SNM for pharmaceutical applications and analysis 4.1 Physical responsive nanomaterials 4.2 Temperature-responsive nanomaterials 4.3 Electrical and electrochemical stimuli-responsive nanomaterials 4.4 Light-responsive nanomaterials 4.5 Magnetic-responsive nanomaterials 4.6 Chemical-responsive nanomaterials 4.7 pH-responsive nanomaterials 4.8 Biological-responsive nanomaterials 5. SNM for agricultural applications 5.1 Nanofertilizers 5.2 Nanopesticides/nanoherbicides/nanobactericides 5.3 Nanosensors 6. SNM in food preservation 6.1 Smart food packaging and security 6.2 Food functionality 6.3 Enhance shelf life of postharvest crops 7. SNM in apparel industry 7.1 Current research trends for smart textile 7.2 Antimicrobial textiles 7.3 Hydrophobicity and oleophobicity in textiles 7.4 Ultraviolet-resistant textiles 7.5 Antistatic properties in textiles 7.6 Electrically conductive textiles 7.7 Energy storage by textiles 7.8 Photonics in textiles 7.9 Self-cleaning textiles 7.10 Sensors on textile 8. SNM in catalysis and energy applications 8.1 Photovoltaics and solar cells 8.2 Fuel cells and batteries 8.3 Application of SNM in renewable energy such as in CO2 conversion, water splitting, etc. 9. Biogenic/bio-inspired nanomaterials 9.1 Use of biogenic /bio-inspired nanomaterials in chemical engineering, tissue engineering, textile manufacturing, nanomedicine, clinical diagnostics (nanobots), electronics, organ implantations biosensors, biological imaging, biomarkers, and cell labeling 10. Pros and Cons of SNM 10.1 Manufacturing advantages 10.2 Energy and electronic advantages 10.3 Medical benefits 10.4 Environmental effects and economic issues 10.5 Risk assessment on humans 11. Can we imagine tomorrow without SNM? 11.1 Future of SNM 11.2 A New Frontier; the convergence of nanotechnology in machine learning and artificial intelligence 11.3 Conclusions