001469456 001__ 1469456
001469456 005__ 20230803003331.0
001469456 022__ $$a2073-4425
001469456 02470 $$ahttps://doi.org/10.3390/genes13101863$$2DOI
001469456 037__ $$aIR
001469456 041__ $$aeng
001469456 245__ $$aChanges Observed in Potential Key Candidate Genes of Peripheral Immunity Induced by Tai Chi among Patients with Parkinson’s Disease
001469456 260__ $$bMDPI
001469456 269__ $$a2022-10-15
001469456 520__ $$aParkinson’s disease (PD) is a common progressive neurodegenerative disease characterized by motor dysfunction. Although the inhibition of inflammation by Tai Chi has been demonstrated to involve a peripheral cytokine response and may play an important role in improving the motor function of PD patients, the related specific molecular mechanisms of the peripheral immune response to Tai Chi are not fully understood. The microarray dataset ‘GSE124676’ for the peripheral immune response to Tai Chi of PD patients was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened and analyzed using weighted gene co-expression network analysis (WGCNA). A total of 136 DEGs were found in the PD patients after Tai Chi, suggesting an effect of Tai Chi on the peripheral immunity of PD patients. The DEGs are mainly involved in neutrophil activation, T-cell activation, and NOD-like receptor and IL-17 signaling pathways. Furthermore, six key candidate genes (FOS, FOSB, JUNB, ZFP36, CAMP and LCN2) that are involved in peripheral inflammation and the inhibition of inflammation induced by Tai Chi were observed. The results in the present study could be conducive to comprehensively understanding the molecular mechanism involved in the effect of Tai Chi on peripheral inflammation in PD patients and providing novel targets for future advanced research.
001469456 6531_ $$aTai Chi
001469456 6531_ $$aParkinson’s disease
001469456 6531_ $$aperipheral inflammation
001469456 6531_ $$aWGCNA
001469456 6531_ $$aDEGs
001469456 7001_ $$aYang, Guanag$$uShanghai Jiao Tong University
001469456 7001_ $$aDong, Qun$$uShanghai Jiao Tong University
001469456 7001_ $$aYang, Huixin$$uHarbin Sport University
001469456 7001_ $$aWang, Fan$$uHarbin Sport University
001469456 7001_ $$aChen, Linwei$$uHarbin Sport University
001469456 7001_ $$aTang, Junze$$uHarbin Sport University
001469456 7001_ $$aHuang, Guoyuan$$uUniversity of Southern Indiana
001469456 7001_ $$aZhao, Ying$$uShanghai Jiao Tong University
001469456 773__ $$tGenes
001469456 8564_ $$97042a432-0712-4c51-b714-bc34b6ecbe63$$s3911248$$uhttps://library.usi.edu/record/1469456/files/genes-13-01863%20%282%29.pdf
001469456 909CO $$ooai:library.usi.edu:1469456$$pGLOBAL_SET
001469456 980__ $$aMANUSCRIPT