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Table of Contents
Intro
Foreword
Preface
Acknowledgements
Contents
1 Introduction and Overview of Cancer Therapeutics
1.1 Introduction
1.2 Tumor Biology and Cancer Development
1.3 Types of Cancer and Grades
1.4 Factors Involved and Cancer Causes
1.5 Cancer Therapeutic Modalities
1.6 Surgeries
1.7 Chemotherapy
1.8 Chemotherapeutic Agent
1.9 Angiogenesis Inhibitors
1.10 Radiotherapy
1.11 Radiation-Based Surgeries
1.12 Techniques Used in Radiation Therapy
1.13 Hormonal Therapy
1.14 Immunotherapy
1.15 Nanostructure-Based Therapeutics
1.16 Miscellaneous Treatment Modalities
1.17 Conclusion
References
2 Transforming Diagnosis and Therapeutics Using Cancer Genomics
2.1 Background
2.1.1 Classical Genomics
2.1.2 Rise in Genomics and Cancer
2.2 Genome-Based Cancer Diagnostic
2.3 Limitations of Cancer Diagnosis and Treatment
2.4 Transforming Cancer Diagnosis from Classical to Advance
2.4.1 Tumor's Location
2.4.2 Histomorphology
2.4.3 Immunohistochemistry
2.4.4 Flow Cytometry
2.4.5 Cancer Biomarkers Discovery
2.4.6 DNA Methylation Group Based Cancer Diagnosis
2.4.7 Sequencing
2.4.8 Panel Testing
2.4.9 Microarray
2.4.10 Third Generation Sequencing
2.5 Genomics Based Characterization of Cancer
2.5.1 Evaluating Genome for Mutations: Genetic Cancer Culprits
2.5.2 Interruption of the Normal Functioning of Tumor Suppressor Genes
2.5.3 Gene Mutations and DNA Repair Systems
2.5.4 Cancer Genome Analysis
2.5.5 Primary Analysis of Data
2.5.6 Secondary Analysis of Data
2.5.7 Squamous Cell Lung Cancers and Its Genomic Characterization
2.5.8 Genomic Analyses of Ovarian Carcinoma
2.6 Transforming Cancer Therapeutics from Classical to Advance
2.6.1 Evolution of Cancer Therapeutics: Traditional to Advance Level
2.6.2 Chemotherapy and Its Limitations
2.6.3 Alkylating Agents
2.6.4 Antimetabolites
2.6.5 Cytotoxic Antibiotics
2.6.6 Revolution of Targeted Therapy
2.6.7 A New Strategy of Immune Checkpoint Inhibitors for Cancer Treatment
2.7 Genomic Study Transforms Cancer Therapeutics to an Advanced Level
2.7.1 Multi-omics and Cancer
2.7.2 Genomics
2.7.3 Transcriptomics
2.7.4 Metabolomics
2.8 Case Studies of Multi-omics
2.9 Conclusion
References
3 Chemotherapy
3.1 Chapter 1
3.1.1 Goals and Principles of Chemotherapy
3.1.2 Chemotherapy Administration
3.2 Chapter 2: Chemotherapeutic Drugs
3.2.1 Mode of Action
3.2.2 Classification of Common Chemotherapeutics
3.2.3 Common Uses of Chemotherapeutics
3.3 Chapter 3
3.3.1 Side-Effects of Chemotherapy
References
4 Radiation Therapies in Cancer
4.1 Introduction
4.2 Basis of Radiation Therapy
4.3 Pathophysiology of Cancer
4.4 Radiation Therapy and the Immune System
4.5 Chemotherapy and Irradiation Interaction
4.6 Clinical Radiation Oncology
4.7 Radiation Oncology Education
Foreword
Preface
Acknowledgements
Contents
1 Introduction and Overview of Cancer Therapeutics
1.1 Introduction
1.2 Tumor Biology and Cancer Development
1.3 Types of Cancer and Grades
1.4 Factors Involved and Cancer Causes
1.5 Cancer Therapeutic Modalities
1.6 Surgeries
1.7 Chemotherapy
1.8 Chemotherapeutic Agent
1.9 Angiogenesis Inhibitors
1.10 Radiotherapy
1.11 Radiation-Based Surgeries
1.12 Techniques Used in Radiation Therapy
1.13 Hormonal Therapy
1.14 Immunotherapy
1.15 Nanostructure-Based Therapeutics
1.16 Miscellaneous Treatment Modalities
1.17 Conclusion
References
2 Transforming Diagnosis and Therapeutics Using Cancer Genomics
2.1 Background
2.1.1 Classical Genomics
2.1.2 Rise in Genomics and Cancer
2.2 Genome-Based Cancer Diagnostic
2.3 Limitations of Cancer Diagnosis and Treatment
2.4 Transforming Cancer Diagnosis from Classical to Advance
2.4.1 Tumor's Location
2.4.2 Histomorphology
2.4.3 Immunohistochemistry
2.4.4 Flow Cytometry
2.4.5 Cancer Biomarkers Discovery
2.4.6 DNA Methylation Group Based Cancer Diagnosis
2.4.7 Sequencing
2.4.8 Panel Testing
2.4.9 Microarray
2.4.10 Third Generation Sequencing
2.5 Genomics Based Characterization of Cancer
2.5.1 Evaluating Genome for Mutations: Genetic Cancer Culprits
2.5.2 Interruption of the Normal Functioning of Tumor Suppressor Genes
2.5.3 Gene Mutations and DNA Repair Systems
2.5.4 Cancer Genome Analysis
2.5.5 Primary Analysis of Data
2.5.6 Secondary Analysis of Data
2.5.7 Squamous Cell Lung Cancers and Its Genomic Characterization
2.5.8 Genomic Analyses of Ovarian Carcinoma
2.6 Transforming Cancer Therapeutics from Classical to Advance
2.6.1 Evolution of Cancer Therapeutics: Traditional to Advance Level
2.6.2 Chemotherapy and Its Limitations
2.6.3 Alkylating Agents
2.6.4 Antimetabolites
2.6.5 Cytotoxic Antibiotics
2.6.6 Revolution of Targeted Therapy
2.6.7 A New Strategy of Immune Checkpoint Inhibitors for Cancer Treatment
2.7 Genomic Study Transforms Cancer Therapeutics to an Advanced Level
2.7.1 Multi-omics and Cancer
2.7.2 Genomics
2.7.3 Transcriptomics
2.7.4 Metabolomics
2.8 Case Studies of Multi-omics
2.9 Conclusion
References
3 Chemotherapy
3.1 Chapter 1
3.1.1 Goals and Principles of Chemotherapy
3.1.2 Chemotherapy Administration
3.2 Chapter 2: Chemotherapeutic Drugs
3.2.1 Mode of Action
3.2.2 Classification of Common Chemotherapeutics
3.2.3 Common Uses of Chemotherapeutics
3.3 Chapter 3
3.3.1 Side-Effects of Chemotherapy
References
4 Radiation Therapies in Cancer
4.1 Introduction
4.2 Basis of Radiation Therapy
4.3 Pathophysiology of Cancer
4.4 Radiation Therapy and the Immune System
4.5 Chemotherapy and Irradiation Interaction
4.6 Clinical Radiation Oncology
4.7 Radiation Oncology Education