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Table of Contents
Preface: A New Disease?
The Human Burden: Epidemiology of Diabetes across the World
The Economic Burden: Direct and Indirect Costs of Diabetes
The Global Burden of Diabetes
The Ecological Approach to Self-Management in Diabetes
Diabetes Outcomes and Social Determinants of Health
Definition, Diagnostic Criteria, Screening, Diagnosis and Classification of Diabetes and Categories of Glucose Intolerance: an Update
Homeostasis of Glucose and Intermediate Metabolism
Pathophysiology of Type 1 Diabetes
Pathophysiology of Type 2 Diabetes
Genetic Determinants of Type 2 Diabetes
Gene Expression Modifications in Type 2 Diabetes
The Immune System and Inflammation in Type 2 Diabetes
Dysfunction and Death of Pancreatic Beta Cells in Type 2 Diabetes
Obesity in the Pathophysiology of Diabetes
Pathogenesis of Gestational Diabetes
Non-Alcoholic Fatty Liver in the Pathogenesis of Diabetes
Microbiota in the Pathogenesis of Diabetes
Diabetes and Circadian Rhythms
Diabetes Management in Europe
Diabetes Management in Asia
Diabetes Management in the Americas
Diabetes Management in the United States
Diabetes Management in Mexico
Diabetes Management in Africa
Diabetes Management in Australia
Evolution of the Patient-Centered Medical Home and Diabetes Care
Outpatient Diabetes Management and the Chronic Care Model
Clinical Practice Guidelines and Diabetes
Evidence-Based Medicine and Diabetes: Contribution of Trials and Mega-Trials
Measuring Diabetes Quality of Care: Clinical Outcomes, Cost-Effectiveness, and Patient Experience of Care
Clinical Inertia and Diabetes Outcomes
The Continuing Challenge of Patient Adherence
Challenges and Scope of Diabetes Self-Care Education and Support
Diabetes and Mental Health
Tools of Self-Care: Self-Monitoring of Blood Glucose and Tele-Health Resources
Continuous Glucose Monitoring in Clinical Practice: Ambulatory Glucose Profile and Advanced Glucose Sensing Technologies
Type 2 Diabetes and Lifestyle Medicine
Evidence and Implementation of Medical Nutrition Therapy in Persons with Diabetes
Evidence and Implementation of Physical Activity and Exercise in Diabetes Management
The Old Oral Antidiabetics
Incretin Therapies: Current Use and Emerging Possibilities
Sodium-Glucose Cotransporter 2 Inhibitors
Use of Insulin in Outpatient Diabetes Management
Insulin Pump Therapy
Diabetes and Hypertension
Diabetes and Atherogenic Dyslipidemia
Obesity and Diabetes
Metabolic and Bariatric Surgery in Diabetes Management
Diabetes and Smoking: The Burden of Evidence
Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperosmolar Non-Ketotic Status
Hypoglycemia: Diagnosis, Management and Prevention
Inpatient Management of Diabetes and Hyperglycemia
Diabetes and Infection
Biochemical Mechanisms of Vascular Complications in Diabetes
Diabetes and Cardiovascular Disease
Diabetes and Stroke: The Role of Glucose Regulation
Peripheral Arterial Disease and Diabetes Mellitus
Ophthalmic Disease in Diabetes
Diabetes and Oral Health
Renal Disease in Diabetes
Peripheral Diabetic Neuropathies
Diabetic Cardiac Autonomic Neuropathy
Autonomic Visceral Neuropathy and Gastrointestinal Disorders
Urologic Complications of Diabetes
Musculoskeletal Complications of Diabetes
Diabetes and the Skin
Foot Complications
Diabetes and Cancer
Diabetes in Children and Adolescents
Pregnancy: Pregestational and Gestational Management
The Elderly with Diabetes
The Artificial Pancreas
Stem-Cell Therapy
Immune-Regulating Interventions
Unproven Therapies for Diabetes
Diabetes Prevention.
The Human Burden: Epidemiology of Diabetes across the World
The Economic Burden: Direct and Indirect Costs of Diabetes
The Global Burden of Diabetes
The Ecological Approach to Self-Management in Diabetes
Diabetes Outcomes and Social Determinants of Health
Definition, Diagnostic Criteria, Screening, Diagnosis and Classification of Diabetes and Categories of Glucose Intolerance: an Update
Homeostasis of Glucose and Intermediate Metabolism
Pathophysiology of Type 1 Diabetes
Pathophysiology of Type 2 Diabetes
Genetic Determinants of Type 2 Diabetes
Gene Expression Modifications in Type 2 Diabetes
The Immune System and Inflammation in Type 2 Diabetes
Dysfunction and Death of Pancreatic Beta Cells in Type 2 Diabetes
Obesity in the Pathophysiology of Diabetes
Pathogenesis of Gestational Diabetes
Non-Alcoholic Fatty Liver in the Pathogenesis of Diabetes
Microbiota in the Pathogenesis of Diabetes
Diabetes and Circadian Rhythms
Diabetes Management in Europe
Diabetes Management in Asia
Diabetes Management in the Americas
Diabetes Management in the United States
Diabetes Management in Mexico
Diabetes Management in Africa
Diabetes Management in Australia
Evolution of the Patient-Centered Medical Home and Diabetes Care
Outpatient Diabetes Management and the Chronic Care Model
Clinical Practice Guidelines and Diabetes
Evidence-Based Medicine and Diabetes: Contribution of Trials and Mega-Trials
Measuring Diabetes Quality of Care: Clinical Outcomes, Cost-Effectiveness, and Patient Experience of Care
Clinical Inertia and Diabetes Outcomes
The Continuing Challenge of Patient Adherence
Challenges and Scope of Diabetes Self-Care Education and Support
Diabetes and Mental Health
Tools of Self-Care: Self-Monitoring of Blood Glucose and Tele-Health Resources
Continuous Glucose Monitoring in Clinical Practice: Ambulatory Glucose Profile and Advanced Glucose Sensing Technologies
Type 2 Diabetes and Lifestyle Medicine
Evidence and Implementation of Medical Nutrition Therapy in Persons with Diabetes
Evidence and Implementation of Physical Activity and Exercise in Diabetes Management
The Old Oral Antidiabetics
Incretin Therapies: Current Use and Emerging Possibilities
Sodium-Glucose Cotransporter 2 Inhibitors
Use of Insulin in Outpatient Diabetes Management
Insulin Pump Therapy
Diabetes and Hypertension
Diabetes and Atherogenic Dyslipidemia
Obesity and Diabetes
Metabolic and Bariatric Surgery in Diabetes Management
Diabetes and Smoking: The Burden of Evidence
Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperosmolar Non-Ketotic Status
Hypoglycemia: Diagnosis, Management and Prevention
Inpatient Management of Diabetes and Hyperglycemia
Diabetes and Infection
Biochemical Mechanisms of Vascular Complications in Diabetes
Diabetes and Cardiovascular Disease
Diabetes and Stroke: The Role of Glucose Regulation
Peripheral Arterial Disease and Diabetes Mellitus
Ophthalmic Disease in Diabetes
Diabetes and Oral Health
Renal Disease in Diabetes
Peripheral Diabetic Neuropathies
Diabetic Cardiac Autonomic Neuropathy
Autonomic Visceral Neuropathy and Gastrointestinal Disorders
Urologic Complications of Diabetes
Musculoskeletal Complications of Diabetes
Diabetes and the Skin
Foot Complications
Diabetes and Cancer
Diabetes in Children and Adolescents
Pregnancy: Pregestational and Gestational Management
The Elderly with Diabetes
The Artificial Pancreas
Stem-Cell Therapy
Immune-Regulating Interventions
Unproven Therapies for Diabetes
Diabetes Prevention.