Pulmonary and critical care considerations of hematopoietic stem cell transplantation / Ayman O. Soubani, editor.
Soubani, Ayman O., editor.
2023
RC644.5
Available Online

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Title Pulmonary and critical care considerations of hematopoietic stem cell transplantation / Ayman O. Soubani, editor.
ISBN 9783031287978 (electronic bk.)
3031287975 (electronic bk.)
9783031287961
3031287967
DOI https://doi.org/10.1007/978-3-031-28797-8
Published Cham : Springer, [2023]
Copyright ©2023
Language English
Description 1 online resource (xxii, 493 pages) : illustrations (some color)
Other Standard Identifiers 10.1007/978-3-031-28797-8 doi
Call Number RC644.5
Dewey Decimal Classification 616.4/10695
Summary This book serves as a guide to the pulmonary and critical care complications of hematopoietic stem cell transplantation (HSCT). HSCT is an important therapeutic modality for a variety of malignant and non-malignant conditions. The outcomes of these patients have been improving and the number of HSCT cases is increasing around the world. These patients, however, continue to have post-transplant complications related to conditioning regimens and graft vs. host disease. Pulmonary complications following HSCT remain a major cause of morbidity and mortality in this patient population. The book begins with an overview of HSCT and graft vs. host disease. Chapters then cover particular complications, including immunological changes in lungs, diffuse alveolar hemorrhage, bronchiolitis obliterans and pulmonary fibrosis. Other complications, including neurologic, renal, gastrointestinal, and cardiac, are covered. Chapters are comprehensive and consistent with each defining the scope of the complication, epidemiology, risk factors, diagnostic approach, management, outcome and predictors of outcome, and future directions. The book provides insight as well on matters that arise during the care of HSCT patients such as provider burnout, nursing care, intensive care unit organization, nutritional support, and pulmonary and physical rehabilitation. This is an ideal guide for pulmonologists, critical care physicians, transplant specialists, oncologists, and relevant trainees caring for patients who have undergone HSCT.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed June 26, 2023).
Added Author Soubani, Ayman O., editor.
Available in Other Form Print version: 9783031287961
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Intro
Foreword I
Foreword II
Preface
Contents
Editor and Contributors
About the Editor
Contributors
1: Hematopoietic Stem Cell Transplantation: An Overview
Introduction
Autologous Stem Cell Transplant
Collection of Stem Cells
Risk Factors of Poor Mobilization
Conditioning Regimen
Allogeneic Stem Cell Transplant
Donor Selection for Allogeneic HSCT
Sources of Hematopoietic Stem Cells
Bone Marrow
Peripheral Blood
Umbilical Cord Blood (UCB)
Conditioning Regimen
Complications of Stem Cell Transplantation
Early Complications

Graft-Versus-Host Disease (GVHD)
Infectious Diseases
Pre-engraftment: From HSCT to Engraftment (Day 0 to +30)
Early Post-engraftment: Day +30-100
Late Post-engraftment: Beyond Day +100
Oral Mucositis
Hemorrhagic Cystitis
Sinusoidal Obstruction Syndrome (SOS)
Transplant-Associated Microangiopathy (TMA)
Late Complications
References
2: An Overview of Graft-Versus-Host Disease
Introduction
Pathophysiology of GVHD
GVHD: Incidence and Impact on Non-relapse Mortality (NRM)
Risk Factors of GVHD
Classification of GVHD
Staging and Grading of Acute GVHD

Staging/Grading of Chronic GVHD
Introduction of the Concept of GVHD Prophylaxis
Introduction of Cyclosporine A for GVHD Prophylaxis
Use of Combination Drugs for GVHD Prophylaxis
Trials Assessing Tacrolimus Versus CsA
Mycophenolate Mofetil (MMF)
Antithymocyte Globulin (ATG) for In Vivo T-Cell Depletion
Posttransplantation Cyclophosphamide (PTCy)
Sirolimus
Ex Vivo T-Cell Depletion for GVHD Prophylaxis
Targeting T-Cell Co-stimulatory Receptors
Treatment of GVHD
Pulmonary Perspectives
References

3: Pulmonary Complications Following Hematopoietic Stem Cell Transplantation: Spectrum, Incidence, Risk Factors, and Outcomes
Introduction
Infectious Complications
Bacterial Complications
Pneumonia
Nocardia
Mycobacterium tuberculosis (MTB)
Nontuberculous Mycobacterial Infections
Viral Complications
Cytomegalovirus
Respiratory Virus Infections (RVI)
SARS-CoV-2
Invasive Fungal Infections
Noninfectious Complications
Idiopathic Pneumonia Syndrome (IPS)
Peri-Engraftment Respiratory Distress Syndrome (PERDS)
Diffuse Alveolar Hemorrhage (DAH)

Cryptogenic Organizing Pneumonia (COP)
Bronchiolitis Obliterans Syndrome (BOS)
Interstitial Lung Disease (ILD)
Pulmonary Hypertension and Pulmonary Veno-Occlusive Disease (PVOD)
Thoracic Air Leak Syndrome (TALS)
Pleural Effusions
Venous Thromboembolic Disease (VTE) and Pulmonary Cytolytic Thrombi (PCT)
Other Noninfectious Complications
Acute Respiratory Failure and Mechanical Ventilation
Diagnostic Considerations of Noninfectious Pulmonary Complications Following HSCT
Conclusion
References
4: Pretransplant Pulmonary Evaluation
Introduction

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