001469753 000__ 06855cam\\2200673\i\4500 001469753 001__ 1469753 001469753 003__ OCoLC 001469753 005__ 20230803003345.0 001469753 006__ m\\\\\o\\d\\\\\\\\ 001469753 007__ cr\un\nnnunnun 001469753 008__ 230618s2023\\\\sz\a\\\\o\\\\\001\0\eng\d 001469753 019__ $$a1382695792 001469753 020__ $$a9783031287978$$q(electronic bk.) 001469753 020__ $$a3031287975$$q(electronic bk.) 001469753 020__ $$z9783031287961 001469753 020__ $$z3031287967 001469753 0247_ $$a10.1007/978-3-031-28797-8$$2doi 001469753 035__ $$aSP(OCoLC)1382690785 001469753 040__ $$aYDX$$beng$$erda$$epn$$cYDX$$dGW5XE$$dEBLCP$$dOCLCF 001469753 049__ $$aISEA 001469753 050_4 $$aRC644.5 001469753 08204 $$a616.4/10695$$223/eng/20230626 001469753 24500 $$aPulmonary and critical care considerations of hematopoietic stem cell transplantation /$$cAyman O. Soubani, editor. 001469753 264_1 $$aCham :$$bSpringer,$$c[2023] 001469753 264_4 $$c©2023 001469753 300__ $$a1 online resource (xxii, 493 pages) :$$billustrations (some color) 001469753 336__ $$atext$$btxt$$2rdacontent 001469753 337__ $$acomputer$$bc$$2rdamedia 001469753 338__ $$aonline resource$$bcr$$2rdacarrier 001469753 500__ $$aIncludes index. 001469753 5050_ $$aIntro -- Foreword I -- Foreword II -- Preface -- Contents -- Editor and Contributors -- About the Editor -- Contributors -- 1: Hematopoietic Stem Cell Transplantation: An Overview -- Introduction -- Autologous Stem Cell Transplant -- Collection of Stem Cells -- Risk Factors of Poor Mobilization -- Conditioning Regimen -- Allogeneic Stem Cell Transplant -- Donor Selection for Allogeneic HSCT -- Sources of Hematopoietic Stem Cells -- Bone Marrow -- Peripheral Blood -- Umbilical Cord Blood (UCB) -- Conditioning Regimen -- Complications of Stem Cell Transplantation -- Early Complications 001469753 5058_ $$aGraft-Versus-Host Disease (GVHD) -- Infectious Diseases -- Pre-engraftment: From HSCT to Engraftment (Day 0 to +30) -- Early Post-engraftment: Day +30-100 -- Late Post-engraftment: Beyond Day +100 -- Oral Mucositis -- Hemorrhagic Cystitis -- Sinusoidal Obstruction Syndrome (SOS) -- Transplant-Associated Microangiopathy (TMA) -- Late Complications -- References -- 2: An Overview of Graft-Versus-Host Disease -- Introduction -- Pathophysiology of GVHD -- GVHD: Incidence and Impact on Non-relapse Mortality (NRM) -- Risk Factors of GVHD -- Classification of GVHD -- Staging and Grading of Acute GVHD 001469753 5058_ $$aStaging/Grading of Chronic GVHD -- Introduction of the Concept of GVHD Prophylaxis -- Introduction of Cyclosporine A for GVHD Prophylaxis -- Use of Combination Drugs for GVHD Prophylaxis -- Trials Assessing Tacrolimus Versus CsA -- Mycophenolate Mofetil (MMF) -- Antithymocyte Globulin (ATG) for In Vivo T-Cell Depletion -- Posttransplantation Cyclophosphamide (PTCy) -- Sirolimus -- Ex Vivo T-Cell Depletion for GVHD Prophylaxis -- Targeting T-Cell Co-stimulatory Receptors -- Treatment of GVHD -- Pulmonary Perspectives -- References 001469753 5058_ $$a3: Pulmonary Complications Following Hematopoietic Stem Cell Transplantation: Spectrum, Incidence, Risk Factors, and Outcomes -- Introduction -- Infectious Complications -- Bacterial Complications -- Pneumonia -- Nocardia -- Mycobacterium tuberculosis (MTB) -- Nontuberculous Mycobacterial Infections -- Viral Complications -- Cytomegalovirus -- Respiratory Virus Infections (RVI) -- SARS-CoV-2 -- Invasive Fungal Infections -- Noninfectious Complications -- Idiopathic Pneumonia Syndrome (IPS) -- Peri-Engraftment Respiratory Distress Syndrome (PERDS) -- Diffuse Alveolar Hemorrhage (DAH) 001469753 5058_ $$aCryptogenic Organizing Pneumonia (COP) -- Bronchiolitis Obliterans Syndrome (BOS) -- Interstitial Lung Disease (ILD) -- Pulmonary Hypertension and Pulmonary Veno-Occlusive Disease (PVOD) -- Thoracic Air Leak Syndrome (TALS) -- Pleural Effusions -- Venous Thromboembolic Disease (VTE) and Pulmonary Cytolytic Thrombi (PCT) -- Other Noninfectious Complications -- Acute Respiratory Failure and Mechanical Ventilation -- Diagnostic Considerations of Noninfectious Pulmonary Complications Following HSCT -- Conclusion -- References -- 4: Pretransplant Pulmonary Evaluation -- Introduction 001469753 506__ $$aAccess limited to authorized users. 001469753 520__ $$aThis book serves as a guide to the pulmonary and critical care complications of hematopoietic stem cell transplantation (HSCT). HSCT is an important therapeutic modality for a variety of malignant and non-malignant conditions. The outcomes of these patients have been improving and the number of HSCT cases is increasing around the world. These patients, however, continue to have post-transplant complications related to conditioning regimens and graft vs. host disease. Pulmonary complications following HSCT remain a major cause of morbidity and mortality in this patient population. The book begins with an overview of HSCT and graft vs. host disease. Chapters then cover particular complications, including immunological changes in lungs, diffuse alveolar hemorrhage, bronchiolitis obliterans and pulmonary fibrosis. Other complications, including neurologic, renal, gastrointestinal, and cardiac, are covered. Chapters are comprehensive and consistent with each defining the scope of the complication, epidemiology, risk factors, diagnostic approach, management, outcome and predictors of outcome, and future directions. The book provides insight as well on matters that arise during the care of HSCT patients such as provider burnout, nursing care, intensive care unit organization, nutritional support, and pulmonary and physical rehabilitation. This is an ideal guide for pulmonologists, critical care physicians, transplant specialists, oncologists, and relevant trainees caring for patients who have undergone HSCT. 001469753 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed June 26, 2023). 001469753 650_0 $$aHematopoietic stem cells$$xTransplantation. 001469753 650_0 $$aHematopoietic stem cell disorders$$xTreatment. 001469753 650_0 $$aCritical care medicine. 001469753 650_0 $$aLungs$$xDiseases. 001469753 655_0 $$aElectronic books. 001469753 7001_ $$aSoubani, Ayman O.,$$eeditor. 001469753 77608 $$iPrint version: $$z3031287967$$z9783031287961$$w(OCoLC)1370926611 001469753 852__ $$bebk 001469753 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-28797-8$$zOnline Access$$91397441.1 001469753 909CO $$ooai:library.usi.edu:1469753$$pGLOBAL_SET 001469753 980__ $$aBIB 001469753 980__ $$aEBOOK 001469753 982__ $$aEbook 001469753 983__ $$aOnline 001469753 994__ $$a92$$bISE