Intro
Foreword
Acknowledgments
Contents
Editors and Contributors
Contributors
Chapter 1: Introduction: Biomedical Research in One World: Current and Future Challenges
References
Part I: Biomedical Research: Genetic and Cell Research
Chapter 2: Learning from Icarus: The Impact of CRISPR on Gene Editing Ethics
Introduction
Brief History of Gene Editing and CRISPR
What Is Ethically Unique About CRISPR?
Who Owns CRISPR, and Does This Matter?
Technical Concerns, Risks, and Benefits
Transparency and Public Deliberation
Informed Consent
Playing God

Solidarity and Justice
Conclusion
References
Chapter 3: Bioethical Decision Making and Genome Editing
Introduction
Determining the Ethical Challenges for Human Beings
Safety Concerns
Distinguishing Different Personal Identities
Non-heritable Genome Editing
Heritable Genome Editing
Advantages of Heritable Genome Editing
Disadvantages of Heritable Genome Editing
Decision-Making in a Practical Context
Gene Editing of Very Early Embryos
Genome Editing of Sperm, Eggs, and During Fertilisation
On What Basis Should a Decision Be Made?
Conclusion

References
Chapter 4: Therapeutic Genome Editing
References
Chapter 5: Bioethical Decision-Making About Somatic Cell Genome Editing: Sickle-Cell Disease as a Case Study
Introduction
What Are Somatic Cells?
Somatic Cells and Disease Etiology
Monogenic and Polygenic Diseases
Historical Development of Somatic Cell Genome Editing
Homologous Recombination
Non-homologous End-Joining
Nuclease-Mediated SCGE
Ex Vivo, In Vivo and In Utero Applications of SCGE
Bioethical Decisions About Nuclease-Mediated SCGE in General
Sickle-Cell Disease

Current Therapeutic Approaches to Sickle-Cell Disease
Bioethical Decision-Making About Hematopoietic Stem Cell Transplantation-Based Cures for Sickle-Cell Disease
The Nuclease-Mediated SCGE Approach to Sickle-Cell Disease
Bioethical Decision-Making About Ex-Vivo Nuclease-Mediated SCGE
Nonmaleficence
Beneficence
Autonomy
Justice
Conclusion
References
Chapter 6: Gene Therapy and Germline Cells Research
Introduction

How Is Germline Gene Therapy Technically Possible? Advancing Germline Genomic Editing Techniques Through CRISPR/Cas9, a Nobel Prize Winning Combination
Gene Therapy: Definitions, Differentiations and Applications
When Do We Really Talk About Germline Gene Therapy? One Step Beyond the Dichotomy Between Therapeutic and Non-Therapeutic
Fear of a Eugenic Drift and the Controversial Violation of Human Dignity: Two Major Bioethical Objections to Germline Gene Therapy
Does Eradicating Disease Mean Eradicating the Sick? Disabilites Rights Critique and Germline Gene Therapy
Conclusions