NADPH oxidases revisited : from function to structure / Edgar Pick, editor.
Pick, Edgar.
2023
QP601
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Title
NADPH oxidases revisited : from function to structure / Edgar Pick, editor.
ISBN
9783031237522 (electronic bk.)
3031237528 (electronic bk.)
303123751X
9783031237515
DOI
https://doi.org/10.1007/978-3-031-23752-2
Publication Details
Cham : Springer, 2023.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-031-23752-2 doi
Call Number
QP601
Dewey Decimal Classification
572.7
Summary
This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed June 29, 2023).
Added Author
Pick, Edgar.
Available in Other Form
Print version: 9783031237515
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Part. I. History, Recollections, And Homages
Paradigm Shifts in the History of Nox2 and Its Regulators: An Appreciative Critique
The Phagocyte Oxidase: The Early Years
Reflections on My Life in Noxes
The Discovery and Characterisation of Nox2, a Personal Journey
Reminiscences on Positional Cloning of X-CGD Gene (Aka CYBB, gp91phox, Nox2)
On Katsuko Kakinuma: Spectroscopic Studies of Redox Centers in NADPH Oxidase Identifying and Observing the Key Players That Pass an Electron to Oxygen
Pierre Vignais, from One Respiratory Chain to Another
Gary M. Bokoch, the Rac-n-Rho Man: His fascination with Rho-GTPases
History and Discovery of the Noxes: From Nox1 to the DUOXes
Part. II. Canonical NADPH Oxidases
NADPH Oxidase 1: At the Interface of the Intestinal Epithelium and Gut Microbiota
Physiological Functions and Pathological Significance of NADPH Oxidase 3
Nox 4: From Discovery to Pathophysiology
Nox5 - Molecular Regulation and Pathophysiology
DUOX1 and DUOX2, DUOXA1 and DUOXA2
Part. III. NADPH Oxidase Regulators
p47phox and NOXO1, the Organizer Subunits of the NADPH Oxidase 2 (Nox2) and NADPH Oxidase 1 (Nox1)
The NADPH Oxidase Activator p67phox and Its Related Proteins
p40phox: Composition, Function and Consequences of Its Absence
Rho Family GTPases and their Modulators
Part IV. Tools, Inhibitors, and Neighbors
Tools to Identify Noxes and their Regulators
Methods to Measure Reactive Oxygen Species Production by NADPH Oxidases
Isoform-Selective Nox Inhibitors: Advances and Future Perspectives
Proteins Cross-talking with Nox Complexes: The Social Life of Noxes
Part V. Non-Mammalian NADPH Oxidases
NADPH Oxidase-Dependent Processes in the Social Amoeba Dictyostelium Discoideum
Discovery and Functional Analysis of the Single-Celled Yeast NADPH Oxidase, Yno1
NADPH Oxidases in Fungi
Plant NADPH Oxidases
Nematode Noxes: The DUOXes of Caenorhabditis elegans
NADPH Oxidases in Arthropods
NADPH Oxidases in Zebrafish
Part VI. Structure
Structural Insights into the Mechanism of DUOX1-DUOXA1 Complex
Structure, Function and Mechanism of Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) Enzymes
Part VII. Pathology
Chronic Granulomatous Disease
Definitive Treatments for Chronic Granulomatous Disease with a Focus on Gene Therapy
Part VIII. Future
Quo Vadis NADPH Oxidases: Perspectives on Clinical Translation.

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