Intro
Preface
Introduction: The Importance of European Perinatology During COVID-19 Pandemics
Contents
Contributors
Part I: Obstetrics
Chapter 1: Clinical Management of COVID-19 During Pregnancy
1.1 Introduction
1.2 Initial Clinical Assessment
1.2.1 Search for Risk Factors of Unfavorable Clinical Outcome (Respiratory Distress)
1.2.2 Search for Signs of Severity and Maternal Complications
1.2.3 Search for Obstetrical Complications
1.3 Management of a Patient with COVID-19 Infection During Pregnancy with Criteria for Hospitalization
1.3.1 Maternal Care

1.3.2 Fetal Management
1.3.3 Fetal Extraction Criteria
1.4 Conclusion
References
Chapter 2: Complications of COVID-19 in Pregnant Women
2.1 Maternal Complications
2.2 Obstetrical Complications
2.2.1 Preeclampsia
2.2.2 Preterm Birth
2.2.3 Stillbirth
References
Chapter 3: Peculiarities of ARDS Induced by COVID-19 in Pregnant Patients
3.1 SARS-CoV-2 Infection and Pregnancy
3.2 Maternal and Neonatal Management of COVID-19 ARDS
3.2.1 Respiratory Support
3.2.2 Prone Position
3.3 Extracorporeal Membrane Oxygenation (ECMO)
3.4 Delivery
References

Chapter 4: Miscarriage and Fetal Death
4.1 Introduction
4.2 Definitions
4.3 Miscarriages
4.4 Fetal Death
4.5 Conclusion
Bibliography
Chapter 5: COVID-19 in Perinatology: Obstetrical Counseling to Pregnant Women During Pandemics
5.1 Clinical Implications of COVID-19 Infection During Pregnancy
5.2 Changes to Obstetric Healthcare During the Pandemic
5.2.1 Prenatal Care
5.2.2 Intrapartum Care
5.2.3 Postnatal Care
5.3 Use of COVID-19-Specific Medication During Pregnancy
5.4 Pregnancy and Pandemics: Lessons for the Future
5.4.1 Prediction

5.4.2 Preparedness
References
Part II: Perinatal Medicine
Chapter 6: Biological Mechanisms of Transplacental SARS-COV-2 Transmission
6.1 The Maternal-Fetal Interface
6.2 SARS-COV-2 Infection: Virus Characteristics (Genomic and Taxonomy)
6.3 SARS-COV-2 and Cell Entry: Mechanism and Receptors
6.4 ACE2 and TMPRSS2: Role in the Placental Transmission
6.5 Latest News
6.6 Conclusions
References
Chapter 7: Placental Pathology During COVID-19
7.1 Introduction
7.2 Role of Placental Pathology in Emerging Infections
7.3 Placental Pathology and COVID-19

7.4 SARS-CoV-2 Placentitis
7.5 Determining Placental Infection with SARS-CoV-2
7.6 Placental Pathology and Stillbirth from COVID-19
References
Chapter 8: Perinatal Diagnostic of SARS-CoV-2 Infection
8.1 Samples Suitable for Testing
8.2 Detecting the Presence of SARS-CoV-2 Virus
8.3 Detecting the Presence of Antibodies Against SARS-CoV-2 Virus
8.4 Interpretation of Virological and Serological Diagnostic Tests in Perinatal SARS-CoV-2 Infection
References
Chapter 9: Vertical SARS-CoV-2 Transmission
9.1 Introduction
9.2 Definitions