Application of Omic techniques to identify new biomarkers and drug targets for COVID-19 / Paul C. Guest, editor.
Guest, Paul C.
2023
RA644.C67
Available Online

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Title Application of Omic techniques to identify new biomarkers and drug targets for COVID-19 / Paul C. Guest, editor.
ISBN 9783031280122 (electronic bk.)
3031280121 (electronic bk.)
3031280113
9783031280115
DOI https://doi.org/10.1007/978-3-031-28012-2
Publication Details Cham, Switzerland : Springer, 2023.
Language English
Description 1 online resource
Item Number 10.1007/978-3-031-28012-2 doi
Call Number RA644.C67
Dewey Decimal Classification 614.5924144
Summary The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed July 10, 2023).
Added Author Guest, Paul C.
Series Advances in experimental medicine and biology ; v. 1412.
Advances in experimental medicine and biology. Proteomics, metabolomics, interactomics and systems biology.
Available in Other Form Print version: 9783031280115
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Intro
Preface
Contents
Part I: Background
Chapter 1: The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology, and Variants of Concern
1 Introduction
2 SARS-CoV-2 Structure
3 SARS-CoV-2 Infection of Host Cells
4 Symptomology
5 Variants of Concern
5.1 Alpha
5.2 Beta
5.3 Gamma
5.4 Delta
5.5 Omicron
6 Conclusions and Future Perspective
References
Chapter 2: Long-Term Vaccination and Treatment Strategies for COVID-19 Disease and Future Coronavirus Pandemics
1 Introduction
2 Current COVID-19 Vaccines

3 Treatments for COVID-19
3.1 Remdesivir
3.2 Anti-Spike Protein Monoclonal Antibodies
3.2.1 Regdanvimab
3.2.2 Casirivimab/Imdevimab Cocktail
3.2.3 Sotrovimab
3.2.4 Tixagevimab/Cilgavimab Cocktail
3.3 Tocilizumab
3.4 Anakinra
3.5 Ritonavir
4 Effect of SARS-CoV-2 Variants on the Efficacy of Vaccines and Monoclonal Antibody Therapeutics
5 Identification of Monoclonal Antibodies and Development of New Vaccines to Overcome the Immune Escape Capabilities of SARS-CoV-2 Variants
5.1 Monoclonal Antibodies
5.2 SARS-CoV-2 Vaccines
5.2.1 Updated Vaccines

5.2.2 Multivalent Vaccines
6 Natural Products for Improved Management of COVID-19 Patients
7 Conclusions and Future Perspectives
References
Part II: Neurological and Psychological Effects of the COVID-19 Pandemic
Chapter 3: Consequences of the Lockdown: Domestic Violence During the COVID-19 Pandemic
1 Introduction
2 Methods
2.1 Participants
2.2 Procedure
2.2.1 Demographic Information
2.2.2 Domestic Violence
2.2.3 Self-Report Measure for the Assessment of Emotion Regulation Skills
2.2.4 Commitment Score
2.2.5 Restrictions Due to Containment Measures

2.2.6 Contact Quality
2.3 Statistical Analyses
3 Results
3.1 Sociodemographic Data
3.2 Gender Differences Regarding Domestic Violence
3.3 Comparison of Domestic Violence Victims and Controls
3.4 Mediator Analyses
4 Discussion
5 Conclusions and Future Perspectives
References
Chapter 4: Psychological Distress Impact of Coronavirus Disease (COVID-19) Outbreak on Three Continents: A Systematic Review and Meta-analysis
1 Introduction
2 Materials and Methods
2.1 Database and Search Strategy
2.2 Eligibility Criteria
2.3 Introducing the CPDI

2.4 Data Extraction
2.5 Quality Assessment
2.6 Statistical Analysis
3 Results
3.1 Search Outcomes
3.2 Study Characteristics
3.3 Pooled Prevalence of Psychological Distress
3.4 Pooled Prevalence of Psychological Distress According to Continents
3.5 Pooled Prevalence of Psychological Distress According to Gender
3.6 Publication Bias
4 Discussion
5 Conclusions and Future Perspectives
References

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