Intro
Preface
Contents
About the Editors
Smart Nanotechnology in Pathological Hypoxia: An Innovative Avenue for a Clinical Hurdle
1 Introduction
1.1 Molecular Responses to Hypoxia-Hypoxia-Inducible Factors and Allied Pathways
2 Smart Nanomaterials
2.1 Smart Nanomaterials Targeting Hypoxic Tissues
References
Bioinspired Nanosystems Interacting with the Host Environment: Smart Nanosystems
1 Introduction
2 Smart Nanosystems in Drug Delivery
3 Targeted Drug Delivery Approaches
4 Bioinspired Nanocarriers
4.1 Lipid Nanostructures

4.2 Lipid Nanoparticles (LNPs)
4.3 Lipid Nanocapsules (LNCs)
4.4 Lipid-Based Micelles
4.5 Viral Vectors
4.6 Liposome-Based Nanocarriers
4.7 Polymeric Nanocarrier
5 Nanorobotics
5.1 Targeted Motion
5.2 Drug Release Mechanism
6 Potential and Limitations of Smart Nanosystem
7 Conclusion
References
Nanotechnology-Based Approaches to Relieve Tumour Microenvironment Hypoxia via Enhanced Oxygen Delivery
1 Introduction
2 Nanotechnology-Based Approaches for O2 Delivery in Hypoxic Site
2.1 Nanochemical Decomposition for O2 Release

2.2 Breakdown of Catalase to Generate O2
2.3 Water-Based Splitting to Produce O2
3 Various Strategically Used Nanomaterials for TME Hypoxia
3.1 PFC-Based Oxygen Carriers (PFOCs) and Fe2+ Porphyrin Systems
3.2 Artificial Red Blood Cells Substitute (RBCSs)
3.3 Metal-Organic Framework (MOFs)
3.4 Oxygen Microcapsules
4 Nanotechnology-Based Therapeutic Approaches for Hypoxia
4.1 Nanoparticles Conquering Hypoxia-Inducing Factor
4.2 Targeting Metastatic Hypoxic Condition by Nanodelivery Against Chemoresistance

4.3 Nanoparticle Relieving: Lowering Hypoxic TME by Immunotherapy
5 Conclusion
References
Recent Progress in Hypoxia-Targeting: Peptide-Based Nanomaterials
1 Introduction
2 Polypeptide-Based Nanoparticles
3 Self-Assembled Peptide-Based Nanoparticles
4 Peptide and Polymer Conjugate Nanoparticles
5 Peptide-Functionalized Liposomes
6 Polysaccharides Functionalization Study by Peptides
7 Conclusion and Outlook for the Future
References
Recent Advancements in the Field of Stimuli-Responsive Polymeric Nanomaterials for Cancer Treatment
1 Introduction

2 Smart Polymeric Nanobiomaterials
2.1 The Preparation Process of Stimuli-Responsive Polymers
3 Physicochemical Characterization
3.1 Single Stimuli-Responsive Smart Materials
3.2 Dual Stimuli-Responsive Smart Materials
3.3 Multi-stimuli-Responsive Smart Materials
4 Anti-tumor Efficiency of Stimuli-Responsive Nanopolymers
4.1 Single Stimuli-Responsive Smart Materials
4.2 Dual Stimuli-Responsive Smart Materials
4.3 Multi-stimuli-Responsive Smart Materials
5 Conclusion
References