001470319 001__ 1470319
001470319 005__ 20230804003237.0
001470319 022__ $$a2218-1989
001470319 02470 $$ahttps://doi.org/10.3390/metabo13040545$$2DOI
001470319 037__ $$aIR
001470319 041__ $$aeng
001470319 245__ $$aMetabolic Inheritance and the Competition for Calories between Mother and Fetus
001470319 260__ $$bMDPI
001470319 269__ $$a2023-04-11
001470319 520__ $$aDuring the prenatal period, maternal and fetal cells compete for calories and nutrients.
To ensure the survival of the mother and development of the fetus, the prenatal hormonal milieu
alters the competitive environment via metabolic perturbations (e.g., insulin resistance). These
perturbations increase maternal caloric consumption and engender increments in both maternal fat
mass and the number of calories captured by the fetus. However, a mother’s metabolic and behavioral
phenotypes (e.g., physical activity levels) and her external environment (e.g., food availability) can
asymmetrically impact the competitive milieu, leading to irreversible changes in pre- and post- natal development—as exhibited by stunting and obesity. Therefore, the interaction of maternal
metabolism, behavior, and environment impact the competition for calories—which in turn creates a
continuum of health trajectories in offspring. In sum, the inheritance of metabolic phenotypes offers
a comprehensive and consilient explanation for much of the increase in obesity and T2DM over the
past 50 years in human and non-human mammals.
001470319 6531_ $$amaternal
001470319 6531_ $$afetal
001470319 6531_ $$acompetition inheritance
001470319 6531_ $$ametabolism
001470319 6531_ $$aobesity
001470319 6531_ $$aT2DM
001470319 7001_ $$aArcher, Edward$$uEvolvingFX LLC
001470319 7001_ $$aLavie, Carl J.$$uThe University of Queensland School of Medicine
001470319 7001_ $$aDobersek, Uska$$uUniversity of Southern Indiana
001470319 7001_ $$aHill, James O.$$uUniversity of Alabama at Birmingham
001470319 773__ $$tMetabolites
001470319 909CO $$ooai:library.usi.edu:1470319$$pGLOBAL_SET
001470319 980__ $$aMANUSCRIPT