Cartilage [electronic resource] : from biology to biofabrication / Mohamadreza Baghaban Eslaminejad, Samaneh Hosseini, editors.

Intro
Preface
Contents
Editors and Contributors
1: Introduction to Cartilage Tissue: Development, Structure, and Functions
1.1 Introduction
1.2 Cartilage Tissue in Mammalian Body
1.3 Articular Cartilage
1.3.1 Origin of Articular Cartilage: Embryology of Cartilage
1.3.2 Postnatal Articular Cartilage Growth and Expansion
1.4 Articular Cartilage Macrostructure
1.4.1 Cartilage Composition
1.4.2 The Mature Cartilage Matrix Structure and Function
1.5 Microstructure of Articular Cartilage: Chondrocyte Structure and Function
1.5.1 Chondrocyte Biology

1.6 Ultrastructure of Adult Articular Cartilage: Articular Cartilage Zone Organization
1.6.1 Radial Structure (The Chondron)
1.7 Biomechanical Functions and Mechanical Characteristics of Articular Cartilage
1.7.1 Compressive Properties of Articular Cartilage
1.7.2 Tensile and Shear Properties
1.7.3 Swelling Behavior of Articular Cartilage
1.8 Metabolism of Articular Cartilage
1.9 Maintaining a Healthy State: Articular Injuries and Disease
1.10 Conclusion
References
2: Cartilage Defects and Diseases: Conventional Therapies and Its Limitations
2.1 Introduction

2.2 OA
2.2.1 Progress and Limitations of Drug Therapy for OA
2.2.2 Progress and Limitations of Non-drug Therapy for OA
2.2.3 Progress and Limitations of Exercise Therapy for OA
2.2.4 Advances and Limitations of Cell Preparations and Stem Cell Therapy for OA
2.2.5 Progress and Limitations of Surgical Treatment of OA
2.3 RA
2.3.1 Progress and Limitations of Drug Therapy for RA
2.3.2 Progress and Limitations of Biologic Therapy for RA
2.3.3 Progress and Limitations of Exercise Therapy in RA
2.4 GA
2.4.1 Progress and Limitations of Drug Therapy for GA

2.4.2 Progress and Limitations of Exercise Therapy in GA
2.5 Conclusion
References
3: Strategies to Control Mesenchymal Stem Cell Differentiation for Regenerating Phenotypically Defined Articular Cartilage
3.1 Introduction
3.2 Spatial and Temporal Influence of Bioactive Factors
3.3 Manipulation of Scaffold Microenvironment for Cartilage Tissue Engineering
3.4 Provision of Biomolecular Cues
3.5 Provision of Physical Cues
3.5.1 Substrate Elasticity
3.5.2 Surface Topography
3.6 Biomaterial Facilitation of Mesenchymal Condensation

3.7 3D Composite Multilayered Scaffolds
3.8 Manipulation of Cell Culture Conditions
3.8.1 Co-Culture Platform
3.8.2 Oxygen Tension
3.8.3 Dynamic Stimulation
3.9 Multifactorial Approach in Stimulating MSC Chondrogenesis
3.10 Future and Conclusion
References
4: Single-Cell Analysis Approaches in Cartilage Diseases Diagnosis and Therapies
4.1 Introduction
4.2 Workflow in Single-Cell Technology
4.2.1 Single-Cell Isolation Technologies
4.2.1.1 Fluorescence-Activated Cell Sorting (FACS)
4.2.1.2 Laser Capture Microdissection (LCM)
4.2.1.3 Microfluidics