001471750 000__ 04928cam\\2200637\i\4500
001471750 001__ 1471750
001471750 003__ OCoLC
001471750 005__ 20230908003313.0
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001471750 008__ 230714s2023\\\\si\a\\\\ob\\\\000\0\eng\d
001471750 020__ $$a9789819915927$$q(electronic bk.)
001471750 020__ $$a9819915929$$q(electronic bk.)
001471750 020__ $$z9789819915910
001471750 020__ $$z9819915910
001471750 0247_ $$a10.1007/978-981-99-1592-7$$2doi
001471750 035__ $$aSP(OCoLC)1390447779
001471750 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dEBLCP$$dOCLCQ
001471750 049__ $$aISEA
001471750 050_4 $$aRA1231.A5
001471750 08204 $$a615.9/25673$$223/eng/20230714
001471750 24500 $$aNeurotoxicity of aluminum /$$cedited by Qiao Niu.
001471750 250__ $$aSecond edition.
001471750 264_1 $$aSingapore :$$bSpringer,$$c2023.
001471750 300__ $$a1 online resource (xviii, 313 pages) :$$billustrations.
001471750 336__ $$atext$$btxt$$2rdacontent
001471750 337__ $$acomputer$$bc$$2rdamedia
001471750 338__ $$aonline resource$$bcr$$2rdacarrier
001471750 4901_ $$aAdvances in experimental medicine and biology
001471750 500__ $$aPrevious edition: 2018.
001471750 504__ $$aIncludes bibliographical references.
001471750 5050_ $$aChapter 1 Overview of the relationship between aluminum exposure and health of human being.-Chapter 2 The Chemistry of Human Exposure to Aluminum -- Chapter 3 Entry and Deposit of Aluminum in Brain -- Chapter 4 Aluminum as a CNS and immune system toxin across the life span.-Chapter 5 Occupational exposure to aluminum and cognitive impairment -- Chapter 6 Debated relationship between Exposure to Aluminum in Daily Life and Alzheimers Disease -- Chapter 7 Animal Model of Aluminum-Induced Alzheimers like Disease -- Chapter 8 Aluminum-induced AD-like Pathological Features.-Chapter 9 Aluminum induced neural cells death -- Chapter 10 Aluminum-Induced Electrophysiological Variation, Synaptic Plasticity Impairment, and Related Mechanism.-Chapter 11 Cross Talk Between Aluminum and Genetic Susceptibility -- Chapter 12 Epigenetic modification in aluminum-induced neuron death and synaptic impairment -- Chapter 13 Neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) -- Chapter 14 Alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects.
001471750 506__ $$aAccess limited to authorized users.
001471750 520__ $$aThis book reviews the scientific literature and the authors own research linking aluminum neurotoxicity with cognitive impairment and Alzheimers disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles and amyloid betathe pathological features of AD, and the possible mechanism of aluminum inducing these pathological features. Further, the book stresses the importance of aluminums complex speciation chemistry in relation to biology, and details aluminums mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metals debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed, and more recently the relationship between aluminum-induced epigenetic modification on DNA and non-coding RNAs and neuron death and synaptic impairment. The second edition updates eight chapters according to the most recent researches. Content about aluminum-induced AD-like pathological features, neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) and alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects is also added. In closing, this book provides readers with a systematic summary of aluminum neurotoxicity.
001471750 588__ $$aDescription based on print version record.
001471750 650_0 $$aAluminum$$xToxicology.
001471750 650_0 $$aAluminum$$xPhysiological effect.
001471750 650_0 $$aNeurotoxicology.
001471750 655_0 $$aElectronic books.
001471750 7001_ $$aNiu, Qiao,$$eeditor.$$1https://isni.org/isni/0000000496970545
001471750 77608 $$iPrint version:$$tNeurotoxicity of aluminum.$$bSecond edition.$$dSingapore : Springer, 2023$$z9789819915910$$w(OCoLC)1388637616
001471750 830_0 $$aAdvances in experimental medicine and biology.
001471750 852__ $$bebk
001471750 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-99-1592-7$$zOnline Access$$91397441.1
001471750 909CO $$ooai:library.usi.edu:1471750$$pGLOBAL_SET
001471750 980__ $$aBIB
001471750 980__ $$aEBOOK
001471750 982__ $$aEbook
001471750 983__ $$aOnline
001471750 994__ $$a92$$bISE