Go to main content

Biological and clinical landscape of meningiomas [electronic resource] / Gelareh Zadeh, Roland Goldbrunner, Boris Krischek, Farshad Nassiri, editors.

Zadeh, Gelareh.; Goldbrunner, Roland.; Krischek, Boris.; Nassiri, Farshad.
2023
RC280.M4
Available Online
Formats
Format
BibTeX
MARCXML
TextMARC
MARC
DublinCore
EndNote
NLM
RefWorks
RIS
Add to Basket
Cite

Linked e-resources

Linked Resource
Online Access
Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks

Details

Title
Biological and clinical landscape of meningiomas [electronic resource] / Gelareh Zadeh, Roland Goldbrunner, Boris Krischek, Farshad Nassiri, editors.
ISBN
9783031297502 (electronic bk.)
3031297504 (electronic bk.)
3031297490
9783031297496
DOI
https://doi.org/10.1007/978-3-031-29750-2
Published
Cham : Springer, 2023.
Language
English
Description
1 online resource (264 pages).
Item Number
10.1007/978-3-031-29750-2 doi
Call Number
RC280.M4
Dewey Decimal Classification
616.99481
Summary
"Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike.".
Note
3.4 Middle Fossa/Temporobasal Meningiomas and Meningiomas of the Lateral and Middle Third of the Lesser Sphenoid Wing
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed July 19, 2023).
Added Author
Zadeh, Gelareh.
Goldbrunner, Roland.
Krischek, Boris.
Nassiri, Farshad.
Series
Advances in experimental medicine and biology ; v. 1416.
Available in Other Form
Biological and Clinical Landscape of Meningiomas
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
All Resources
Intro
Foreword
Acknowledgments
Contents
About the Contributors
Paradigm Shift in the Treatment of Meningiomas
1 Treatment Timeline
2 Epidemiology
3 Treatment
4 Histology, Grading, and Molecular Biology
5 Status Quo
References
Clinical Presentation and Prognosis
1 Clinical Presentation
1.1 General Symptoms
Epilepsy/Seizures
Headache and Raised Intracranial Pressure
Cognitive Function and Psychiatric Manifestations
1.2 Focal Symptoms
Cranial Nerve Deficits
Cortical Compression Syndromes
1.3 Incidental Meningiomas

2 Prognosis
2.1 Histological Grade
2.2 Extent of Resection
2.3 Anatomical Location
Skull Base Tumors
Venous Sinus Invasion
2.4 Molecular Factors and Prognosis
NF2
TRAF7, AKT1, and KLF4
Smoothened
PI3KCA
POLR2
TERT
FOXM1
2.5 Epigenetic Changes: Methylation-Based Classification
3 Conclusions and Future Directions
References
Imaging Characteristics of Meningiomas
1 Imaging Findings in Meningioma on Anatomical CT and MRI
2 Alternative Imaging Methods
3 Advanced MRI
4 Most Relevant Clinical Applications for Advanced MRI

4.1 Differential Diagnosis
5 Meningioma Grading
6 Meningioma Relapse Risk Stratification
7 Molecular PET Imaging
8 Selected Tracers for PET Imaging in Meningioma Patients
8.1 Glucose PET
9 PET Ligands for Somatostatin Receptors
10 Amino Acid PET Tracers
11 Clinical Applications for PET Imaging
11.1 Meningioma Detection and Delineation
12 Radiotherapy Planning
13 Diagnosis of Meningioma Relapse
14 PET-Based Theranostics in Patients with Meningioma
15 Conclusions
References
Histopathology of Meningiomas
1 Introduction

2 Gross Pathology
3 Intraoperative Cytology
4 Histological Variants and Grading
4.1 Meningothelial Meningioma
4.2 Fibrous/Fibroblastic Meningioma
4.3 Transitional Meningioma
4.4 Psammomatous Meningioma
4.5 Angiomatous/Vascular Meningioma
4.6 Microcystic Meningioma
4.7 Secretory Meningioma
4.8 Lymphoplasmacyte-Rich Meningioma
4.9 Metaplastic Meningiomas
4.10 WHO Grade 2 and Grade 3 Meningiomas
4.11 Atypical Meningioma
4.12 Clear Cell Meningiomas
4.13 Chordoid Meningioma
4.14 Anaplastic/Malignant Meningioma

4.15 Papillary Meningioma
4.16 Rhabdoid Meningioma
4.17 Rare Morphological Variants
5 Immunohistochemistry
6 Electron Microscopy
7 Differential Diagnosis
References
Skull Base Meningiomas
1 Introduction
2 Meningiomas of the Anterior Skull Base
2.1 Olfactory Grove Meningiomas
2.2 Meningiomas of the Planum Sphenoidale
2.3 Tuberculum Sellae Meningiomas
2.4 Orbital or Spheno-Orbital Meningiomas
3 Meningiomas of the Middle Skull Base
3.1 Clinoidal Meningiomas
3.2 Medial Sphenoid Wing Meningiomas
3.3 Cavernous Sinus Meningiomas

Browse Subjects

Show more subjects...

Statistics

from
to
Export