Introduction to quality by design in pharmaceutical manufacturing and analytical development / Márcia Cristina Breitkreitz, Hector Goicoechea, editors.
Breitkreitz, Márcia Cristina, editor.; Goicoechea, Hector, editor.
2023
RS420
Available Online

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Title Introduction to quality by design in pharmaceutical manufacturing and analytical development / Márcia Cristina Breitkreitz, Hector Goicoechea, editors.
ISBN 9783031315053 (electronic bk.)
3031315057 (electronic bk.)
3031315049
9783031315046
DOI https://doi.org/10.1007/978-3-031-31505-3
Published Cham : Springer, 2023.
Language English
Description 1 online resource (x, 266 pages) : illustrations (some color).
Other Standard Identifiers 10.1007/978-3-031-31505-3 doi
Call Number RS420
Dewey Decimal Classification 615.19
Summary Written by twenty-five authors from academia, pharmaceutical industry and Pharmacopeias worldwide, this monograph covers the fundamentals and applications of Quality by Design (QbD) and Analytical Quality by Design (AQbD) in a practical and didactic manner. The book starts by describing the motivation and the urgent need for the implementation of the QbD framework in pharmaceutical development, along with the definition of its major elements: Quality Target Product Profile (QTTP), Critical Quality Attributes (CQAs), Critical Process Parameters (CPPs), Critical Material Attributes (CMAs) and the importance of using multivariate methods of Design of Experiments (DOE). The concept of life cycle and regulatory perspectives are discussed. Three chapters are entirely dedicated to DOE theory from screening to optimization designs. Moreover, a comprehensive discussion on modelling and data treatment is presented. Practical aspects of QbD and DOE for pharmaceutical product and process of different dosage forms is included, as well as a practical guide of the input process variables, material attributes, intermediate, and final quality attributes for the most representative pharmaceutical processes. Analytical Quality by Design (AQbD) is also deeply explored, including risk analysis, definitions of Analytical Target Profile (ATP), Method Operable Design Region (MODR) and the life cycle approach, taking into account the compendial and regulatory perspectives. A detailed example of a new chromatographic method for the quality control of a pharmaceutical topical product based on the AQbD procedure is shown. Finally, advanced statistical approaches and DOE methods for extraction studies of bioactive compounds are also presented. The vast amount of information offered in this book provides a comprehensive perspective on QbD, AQbD and DOE principles, essential tools for modern pharmaceutical and analytical development.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed July 19, 2023).
Added Author Breitkreitz, Márcia Cristina, editor.
Goicoechea, Hector, editor.
Series AAPS introductions in the pharmaceutical sciences, 2522-8358
Available in Other Form Print version: 9783031315046
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Part 1: Quality by Design (QbD)
Chapter 1. Pharmaceutical Quality by Design (QbD) overview and major elements
Chapter 2. Fundamentals of design of experiments and optimization: designs for factor screening and data analysis in pre-response surface methodology
Chapter 3. Fundamentals of design of experiments and optimization: experimental designs in response surface methodology
Chapter 4. Fundamentals of design of experiments and optimization: data modeling in response surface methodology
Chapter 5. Quality by Design in pharmaceutical product and process development
Chapter 6. A Quality by Design update on nano-drug delivery systems
Chapter 7. Control strategies of solid dosage forms by PAT tools
Part 2: Analytical Quality by Design (AQbD)
Chapter 8. Analytical Quality by Design Fundamentals, Compendial and Regulatory Perspectives
Chapter 9. Analytical Target Profile (ATP) and Method Operable Design Region (MODR)
Chapter 10: Quality by Design applications to development of analytical methods for quality control of pharmaceuticals
Chapter 11. Design of Experiments Applied to the Extraction of Active Compounds.

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