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Oncodermatology [electronic resource] : an evidence-based, multidisciplinary approach to best practices / Cristina Martinez Zugaib Abdalla, Jos ̌Antonio Sanches, Rodrigo Ramella Munhoz, Francisco Aparecido Belfort, editors.

Abdalla, Cristina Martinez Zugaib.; Sanches, Jos ̌Antonio.; Munhoz, Rodrigo Ramella.; Belfort, Francisco Aparecido.
2023
RC280.S5
Available Online
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Title
Oncodermatology [electronic resource] : an evidence-based, multidisciplinary approach to best practices / Cristina Martinez Zugaib Abdalla, Jos ̌Antonio Sanches, Rodrigo Ramella Munhoz, Francisco Aparecido Belfort, editors.
ISBN
9783031292774 (electronic bk.)
3031292774 (electronic bk.)
3031292766
9783031292767
DOI
https://doi.org/10.1007/978-3-031-29277-4
Published
Cham : Springer, 2023.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-031-29277-4 doi
Call Number
RC280.S5
Dewey Decimal Classification
616.99/477
Summary
The purpose of this book is to outline the topics that are critical in the dermatological approach to patients with cancer. The work discusses the value of a multidisciplinary approach, presents case examples, including some from the Hospital Srio-Libans, a pioneer institution in the treatment of cancer. In all, the book collates the best global evidence for the dermatologic care of patients with cancer, skin cancer, and solid organ and bone-marrow transplanted patients. The clinical, surgical, pathologic, imaging, radiotherapy, oncologic, and palliative care aspects of the dermatologic care of cancer patients is covered. Chapters also discuss subjects such as genetics, biology, evidence-based medicine, and new diagnostic methods and tools like dermoscopy and confocal microscopy. The content is based on the following key areas: educating clinicians on how to prevent skin cancer in patients, screening and counseling, diagnosis and treatment of pigmented lesions, melanoma and nonmelanoma skin cancer, cutaneous lymphomas, sarcomas, leukemic and lymphomatous infiltrations, cutaneous metastases, cutaneous paraneoplasic manifestations and cutaneous adverse reactions to chemotherapy and radiation treatment. The primary audiences are dermatologists, oncologists, radioncologists and oncologic surgeons. The secondary audience are residents and students in these fields. The goal is to prepare and update all specialists on this important clinical and research area.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed July 28, 2023).
Added Author
Abdalla, Cristina Martinez Zugaib.
Sanches, Jos ̌Antonio.
Munhoz, Rodrigo Ramella.
Belfort, Francisco Aparecido.
Available in Other Form
Print version: 9783031292767
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Intro
Contents
Contributors
Chapter 1: Diagnosing and Management of Skin Cancer: A Multidisciplinary Approach
Introduction
The Team
The Goals
References
Chapter 2: Basic Concepts of Carcinogenesis and Immunopathology
The Structure and Function of Normal Skin
The Dark Side of the Sun and the p53 Protection
Are a Few Specific Wrong Letters Enough to Trigger Cancer?
"Cancer Was Not Disorganized Chromosomal Chaos. It Was Organized Chromosomal Chaos"
Receptor Tyrosine Kinases (RTK)
Neurofibromin (NF1)
MAPK Pathway
PI3K/AKT/MTOR Pathway

Phosphatase and Tensin Homolog (PTEN)
Hh Signaling Pathway
P53
CDKs and CDKs-Inhibitors
TERT Activation
Mechanisms of Metastasis: Where No Tumor Cell Has Gone Before
Immunology of Skin Tumors
Tumor Immune Surveillance
Innate Immune Surveillance Cells: The Sentinels for Danger
Adaptive Immune Response
A Paradox Lies at the Heart of Cancer Immunology
Final Remarks
References
Chapter 3: Epidemiology of Skin Cancer
Introduction
Non-melanoma Skin Cancer
Risk Factors
Melanoma
Risk Factors
References
Chapter 4: Risk Factors for Skin Cancer

Introduction
Environmental Risk Factors for Skin Cancer
Physical Environmental Risk Factors
Ultraviolet Radiation
Sun Exposure Pattern
Skin Types
Sociodemographic Characteristics
Indoor Tanning (Tanning Bed/Sunbed)
Other Conditions
Ionizing Radiation
Chemical Risk Factors
Arsenic Exposure
Radon Exposure
Medications
Immunosuppression
Biological Agents (Virus)
Other Risk Factors
Hereditary Cancer Predisposition Syndrome Predisposing to Non-melanoma Skin Cancer
Gorlin Syndrome (Basal Cell Nevus Syndrome, Gorlin-Goltz Syndrome or Nevoid BCC)

Bazex-Dupre-Christol Syndrome (Follicular Atrophoderma with BCC)
Xeroderma Pigmentosum
Rothmund-Thomson Syndrome
Muir-Torre Syndrome
Hereditary Cancer Predisposition Syndromes Predisposing to Melanoma
Hereditary Melanoma Syndrome Related to CDKN2A Gene
Hereditary Melanoma Syndrome Related to CDKN2A Mutations Affecting p14ARF Transcript
Hereditary Melanoma Syndrome Related to CDK4 Gene
Hereditary Melanoma Syndrome Related to TERT
Hereditary Melanoma Syndrome Related to Shelterin Complex Genes: POT1, ACD and TERF2IP
Hereditary Melanoma Syndrome Related to MITF Gene

Hereditary Melanoma Syndrome Related to MC1R Gene
Hereditary Melanoma Syndrome Related to BAP1 Gene
Li-Fraumeni Syndrome
Hereditary Breast and Ovarian Cancer Syndrome Due to Pathogenic Variants in BRCA1 and BRCA2 Genes
Genetic Counseling and Risk Assessment in Cancer Predisposition Syndromes
References
Chapter 5: Principles of the Dermatologic Assessment of Cutaneous Lesions
Primary Lesions
Primary Skin Lesions with Liquid-Filled Lesions
Abscess
Bullae/Blister
Cyst
Hematoma
Pustule
Vesicle
Flat Primary Skin Lesions
Macule
Patch
Telangiectasias

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