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001472073 001__ 1472073
001472073 003__ OCoLC
001472073 005__ 20230908003328.0
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001472073 019__ $$a1391437603
001472073 020__ $$a9789819931859$$q(electronic bk.)
001472073 020__ $$a9819931851$$q(electronic bk.)
001472073 020__ $$z9789819931842
001472073 020__ $$z9819931843
001472073 0247_ $$a10.1007/978-981-99-3185-9$$2doi
001472073 035__ $$aSP(OCoLC)1391327223
001472073 040__ $$aYDX$$beng$$erda$$epn$$cYDX$$dGW5XE$$dEBLCP$$dOCLCQ
001472073 049__ $$aISEA
001472073 050_4 $$aRC269
001472073 08204 $$a616.99/407$$223/eng/20230803
001472073 24500 $$aCancer stem cells :$$bbasic concept and therapeutic implications /$$cFarhadul Islam, Alfred K. Lam, editors.
001472073 264_1 $$aSingapore :$$bSpringer,$$c[2023]
001472073 264_4 $$c©2023
001472073 300__ $$a1 online resource (xvi, 372 pages)
001472073 336__ $$atext$$btxt$$2rdacontent
001472073 337__ $$acomputer$$bc$$2rdamedia
001472073 338__ $$aonline resource$$bcr$$2rdacarrier
001472073 5050_ $$aIntro -- Foreword -- Preface -- Acknowledgment -- Contents -- Editors and Contributors -- 1: Introduction and Perspective in Carcinogenesis -- 1.1 Introduction -- 1.2 Cancer Stem Cells (CSCs): Origin and Roles in Carcinogenesis -- 1.3 Detection and Isolation of CSCs in Various Cancers -- 1.4 Clinical Significance of CSCs -- 1.5 Future Perspective: Therapeutics Targeting CSC -- 1.6 Conclusion -- References -- 2: Origin and Development of Cancer Stem Cells -- 2.1 Introduction -- 2.2 Stem Cell Definition -- 2.3 Stem Cell Models -- 2.4 Cancer Two-Step Model
001472073 5058_ $$a2.5 History of Cancer Stem Cells (CSCs) -- 2.5.1 Nineteenth Century -- 2.5.2 Twentieth Century -- 2.5.3 Twenty-First Century -- 2.5.4 Symmetric and Asymmetric Model of CSC Development -- 2.5.5 Genetic Mutations and Signaling Model of CSC Development -- 2.5.6 Microenvironment Model of CSC Development -- 2.5.7 Embryonic Model of CSC Development -- 2.6 Conclusions -- References -- 3: Detection and Isolation of Cancer Stem Cells -- 3.1 Introduction -- 3.2 Detection and Isolation of Stem Cell -- 3.3 Expansion to CSCs: Cell Sorting Methods -- 3.4 The Leukemia Stem Cell: Initial Biomarkers
001472073 5058_ $$a3.5 Transition to Solid Tumor CSCs: Biomarker Variability -- 3.6 Focus on CSC Quiescence: Side Population (SP) Analysis -- 3.7 Functional Isolation: In Vitro Tumorsphere, Tumorigenicity, and Chemoresistance Assays -- 3.8 Current State of Isolation and Detection Methods: Concluding Statements -- References -- 4: The Genetic and Epigenetic Landscape of Cancer Stem Cells -- 4.1 Introduction -- 4.2 Genetics of Cancer Stem Cells -- 4.3 Epigenetics of Cancer Stem Cells -- 4.4 Histone Modification -- 4.5 DNA Methylation -- 4.6 Chromatin Remodeling -- 4.7 Noncoding RNAs
001472073 5058_ $$a4.8 Genetic and Epigenetic Makeup of CSC and Inflammation -- 4.9 Clinical Significance of CSC Genetic and Epigenetic Changes -- 4.10 Concluding Remarks/Conclusion -- References -- 5: Metabolism of Cancer Stem Cell -- 5.1 Introduction -- 5.2 The Metabolic Profile of Cancer Cells -- 5.3 The Metabolic Profile of CSCs -- 5.3.1 Primary Glycolytic CSCs -- 5.3.2 Oxidative Phosphorylation (OXPHOS)-Dependent CSCs -- 5.3.3 Glutamine Metabolism in CSCs -- 5.3.4 Lipid Metabolism in CSCs -- 5.4 Metabolic Complexity of CSCs -- 5.5 Roles of Mitochondria in CSC Phenotype
001472073 5058_ $$a5.6 Therapeutics Targeting Metabolism of CSC -- 5.7 Concluding Remarks and Challenges Ahead -- References -- 6: Plasticity of Cancer Stem Cell -- 6.1 Introduction -- 6.2 CSCs Capture the Developmental Program of Normal Stem Cell -- 6.3 Tumor Microenvironment and Plasticity of CSCs -- 6.4 Metabolic Adaptation in the Plasticity of CSCs -- 6.5 Epigenetic Regulation of Plasticity in CSCs -- 6.6 Therapy Resistance and CSC Plasticity -- 6.7 Conclusion -- References -- 7: Cancer Stem Cells in Cancer Initiation and Progression -- 7.1 Introduction -- 7.2 Introduction to Cancer Stem Cells
001472073 506__ $$aAccess limited to authorized users.
001472073 520__ $$aThis book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
001472073 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed August 3, 2023).
001472073 650_0 $$aCancer cells.
001472073 650_0 $$aStem cells.
001472073 655_0 $$aElectronic books.
001472073 7001_ $$aIslam, Farhadul,$$eeditor.
001472073 7001_ $$aLam, Alfred K.,$$eeditor.
001472073 77608 $$iPrint version: $$z9819931843$$z9789819931842$$w(OCoLC)1376736705
001472073 852__ $$bebk
001472073 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-99-3185-9$$zOnline Access$$91397441.1
001472073 909CO $$ooai:library.usi.edu:1472073$$pGLOBAL_SET
001472073 980__ $$aBIB
001472073 980__ $$aEBOOK
001472073 982__ $$aEbook
001472073 983__ $$aOnline
001472073 994__ $$a92$$bISE