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001472108 001__ 1472108
001472108 003__ OCoLC
001472108 005__ 20230908003330.0
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001472108 019__ $$a1391443561
001472108 020__ $$a9783031324291$$q(electronic bk.)
001472108 020__ $$a3031324293$$q(electronic bk.)
001472108 020__ $$z9783031324284
001472108 020__ $$z3031324285
001472108 0247_ $$a10.1007/978-3-031-32429-1$$2doi
001472108 035__ $$aSP(OCoLC)1391434016
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001472108 049__ $$aISEA
001472108 050_4 $$aRC280.N4
001472108 08204 $$a616.99/48$$223/eng/20230803
001472108 24500 $$aCancer neuroscience /$$cMoran Amit, Nicole N. Scheff, editors.
001472108 264_1 $$aCham :$$bSpringer,$$c[2023]
001472108 264_4 $$c©2023
001472108 300__ $$a1 online resource (xii, 202 pages) :$$billustrations (chiefly color)
001472108 336__ $$atext$$btxt$$2rdacontent
001472108 337__ $$acomputer$$bc$$2rdamedia
001472108 338__ $$aonline resource$$bcr$$2rdacarrier
001472108 500__ $$aIncludes index.
001472108 5050_ $$aIntro -- Preface -- Contents -- Introduction -- Part I: Cancer and the Central Nervous System -- Chapter 1: Neuronal Activity in Brain Tumor Pathogenesis: Adding to the Complexities of Central Nervous System Neoplasia -- Cellular Origins of Glioma -- Effect of Neuronal Activity on NSC Dynamics -- Effect of Neuronal Activity on OPC Dynamics -- Neuron-OPC Synapses -- Activity-Dependent Pathogenesis of Gliomas -- Activity-Dependent Mitogens for Glioma -- Activity-Dependent Glioma Initiation in Cancer Predisposition Syndromes -- Neuron-Glioma Synapses
001472108 5058_ $$aEffect of Synaptogenic Factors on Neuron-Glioma Synapses -- Gap Junctions in Brain Tumors -- Extracellular Vesicles as Potential Activity-Dependent Factors in Brain Tumor Pathogenesis -- Targeting Neuron-Tumor Interactions in the CNS -- Conclusion -- References -- Chapter 2: Neuron-Cancer Synaptic and Other Electrical Signaling -- References -- Chapter 3: Mechanisms of Cancer-Induced Remodeling of the Central Nervous System -- Neuronal Regulation of Glioma -- Neuronal Activity-Dependent Regulation of Glioma Growth and Progression -- Molecular Mechanisms of Neuronal Regulation of Glioma Growth
001472108 5058_ $$aActivity-Regulated Secretion of Paracrine Factors -- Neurotrophins -- Neurotransmitters -- Neuronal Activity-Evoked Direct Electrochemical Signaling -- Neuronal Activity-Dependent Regulation of Glioma Initiation -- Neuronal Activity-Dependent Regulation of Glioma Invasion -- Neuronally Driven Glioma-Glioma Connections -- Glioma Regulation of Neuronal Excitability -- Glioma-Induced Neuron-Neuron Connections and Network Remodeling -- Therapeutic Implications and Future Work -- References -- Part II: Cancer and the Peripheral Nervous System
001472108 5058_ $$aChapter 4: Neural Influence on Cancer Invasion and Metastasis -- Introduction -- Nerve Structure -- Influence of Cells Within Nerves on Tumor Invasion and Metastasis -- Neuronal Cells -- Direct Effect on Tumor Cells -- Effects on the Tumor Microenvironment -- Schwann Cells -- Direct Effects on Tumor Cells -- Effects on Tumor Microenvironment -- Endoneurial Macrophages -- Summary -- References -- Chapter 5: Cancer Induced Remodeling of the Peripheral Nervous System -- Tumor Profiling Promotes Differences in Innervation and Peripheral Nerve Remodeling -- Cancer-Mediated Remodeling Mechanisms
001472108 5058_ $$aRemodeling by Cancer-Secreted Proteins and Cytokines -- Remodeling by Transfer of Genetic Material -- Remodeling by Cellular Stress and Dysfunction -- Recent Advancements and Future Directions -- References -- Chapter 6: Neuroimmune Interactions and Their Role in Carcinogenesis -- Introduction -- Neuronal-Dependent Immune Regulation -- Sensory Nerve-Mediated Immune Reactions -- Substance P -- Adrenergic Signaling-Mediated Immune Signaling -- Cholinergic Signaling-Mediated Immune Signaling -- The Nonneuronal Release of Neurotransmitters -- Checkpoint-Mediated Neuronal Immune Regulation
001472108 506__ $$aAccess limited to authorized users.
001472108 520__ $$aThis volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
001472108 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed August 3, 2023).
001472108 650_0 $$aNervous system$$xCancer.
001472108 650_0 $$aNeurosciences.
001472108 655_0 $$aElectronic books.
001472108 7001_ $$aAmit, Moran,$$eeditor.
001472108 7001_ $$aScheff, Nicole N.,$$eeditor.
001472108 77608 $$iPrint version: $$z3031324285$$z9783031324284$$w(OCoLC)1374820793
001472108 852__ $$bebk
001472108 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-32429-1$$zOnline Access$$91397441.1
001472108 909CO $$ooai:library.usi.edu:1472108$$pGLOBAL_SET
001472108 980__ $$aBIB
001472108 980__ $$aEBOOK
001472108 982__ $$aEbook
001472108 983__ $$aOnline
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