Cancer neuroscience / Moran Amit, Nicole N. Scheff, editors.
Amit, Moran, editor.; Scheff, Nicole N., editor.
2023
RC280.N4
Available Online

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Title
Cancer neuroscience / Moran Amit, Nicole N. Scheff, editors.
ISBN
9783031324291 (electronic bk.)
3031324293 (electronic bk.)
9783031324284
3031324285
DOI
https://doi.org/10.1007/978-3-031-32429-1
Published
Cham : Springer, [2023]
Copyright
©2023
Language
English
Description
1 online resource (xii, 202 pages) : illustrations (chiefly color)
Item Number
10.1007/978-3-031-32429-1 doi
Call Number
RC280.N4
Dewey Decimal Classification
616.99/48
Summary
This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed August 3, 2023).
Added Author
Amit, Moran, editor.
Scheff, Nicole N., editor.
Available in Other Form
Print version: 9783031324284
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Intro
Preface
Contents
Introduction
Part I: Cancer and the Central Nervous System
Chapter 1: Neuronal Activity in Brain Tumor Pathogenesis: Adding to the Complexities of Central Nervous System Neoplasia
Cellular Origins of Glioma
Effect of Neuronal Activity on NSC Dynamics
Effect of Neuronal Activity on OPC Dynamics
Neuron-OPC Synapses
Activity-Dependent Pathogenesis of Gliomas
Activity-Dependent Mitogens for Glioma
Activity-Dependent Glioma Initiation in Cancer Predisposition Syndromes
Neuron-Glioma Synapses

Effect of Synaptogenic Factors on Neuron-Glioma Synapses
Gap Junctions in Brain Tumors
Extracellular Vesicles as Potential Activity-Dependent Factors in Brain Tumor Pathogenesis
Targeting Neuron-Tumor Interactions in the CNS
Conclusion
References
Chapter 2: Neuron-Cancer Synaptic and Other Electrical Signaling
References
Chapter 3: Mechanisms of Cancer-Induced Remodeling of the Central Nervous System
Neuronal Regulation of Glioma
Neuronal Activity-Dependent Regulation of Glioma Growth and Progression
Molecular Mechanisms of Neuronal Regulation of Glioma Growth

Activity-Regulated Secretion of Paracrine Factors
Neurotrophins
Neurotransmitters
Neuronal Activity-Evoked Direct Electrochemical Signaling
Neuronal Activity-Dependent Regulation of Glioma Initiation
Neuronal Activity-Dependent Regulation of Glioma Invasion
Neuronally Driven Glioma-Glioma Connections
Glioma Regulation of Neuronal Excitability
Glioma-Induced Neuron-Neuron Connections and Network Remodeling
Therapeutic Implications and Future Work
References
Part II: Cancer and the Peripheral Nervous System

Chapter 4: Neural Influence on Cancer Invasion and Metastasis
Introduction
Nerve Structure
Influence of Cells Within Nerves on Tumor Invasion and Metastasis
Neuronal Cells
Direct Effect on Tumor Cells
Effects on the Tumor Microenvironment
Schwann Cells
Direct Effects on Tumor Cells
Effects on Tumor Microenvironment
Endoneurial Macrophages
Summary
References
Chapter 5: Cancer Induced Remodeling of the Peripheral Nervous System
Tumor Profiling Promotes Differences in Innervation and Peripheral Nerve Remodeling
Cancer-Mediated Remodeling Mechanisms

Remodeling by Cancer-Secreted Proteins and Cytokines
Remodeling by Transfer of Genetic Material
Remodeling by Cellular Stress and Dysfunction
Recent Advancements and Future Directions
References
Chapter 6: Neuroimmune Interactions and Their Role in Carcinogenesis
Introduction
Neuronal-Dependent Immune Regulation
Sensory Nerve-Mediated Immune Reactions
Substance P
Adrenergic Signaling-Mediated Immune Signaling
Cholinergic Signaling-Mediated Immune Signaling
The Nonneuronal Release of Neurotransmitters
Checkpoint-Mediated Neuronal Immune Regulation

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