001476060 000__ 07258cam\\22007097a\4500 001476060 001__ 1476060 001476060 003__ OCoLC 001476060 005__ 20231003174630.0 001476060 006__ m\\\\\o\\d\\\\\\\\ 001476060 007__ cr\un\nnnunnun 001476060 008__ 230819s2023\\\\sz\\\\\\o\\\\\000\0\eng\d 001476060 019__ $$a1394115759 001476060 020__ $$a9783031348471$$q(electronic bk.) 001476060 020__ $$a3031348478$$q(electronic bk.) 001476060 020__ $$z303134846X 001476060 020__ $$z9783031348464 001476060 0247_ $$a10.1007/978-3-031-34847-1$$2doi 001476060 035__ $$aSP(OCoLC)1394120865 001476060 040__ $$aEBLCP$$beng$$cEBLCP$$dGW5XE$$dEBLCP$$dYDX$$dOCLCQ$$dSFB$$dOCLCO 001476060 049__ $$aISEA 001476060 050_4 $$aRC280.L8 001476060 08204 $$a616.99/42406$$223/eng/20230825 001476060 24500 $$aAdvances in radiation oncology in lung cancer /$$cBranislav Jeremić, editor. 001476060 250__ $$a3rd ed. 001476060 260__ $$aCham :$$bSpringer,$$c2023. 001476060 300__ $$a1 online resource (1128 p.). 001476060 4901_ $$aMedical Radiology 001476060 500__ $$aPlace and Role of PET/CT in the Diagnosis and Staging of Lung Cancer 001476060 5050_ $$aIntro -- Preface -- Contents -- Part I: Basic Science of Lung Cancer -- Genomic Alterations in Lung Cancer -- 1 Introduction -- 2 NSCLC -- 3 EGFR -- 4 ALK -- 5 ROS1 -- 6 BRAF -- 7 MET -- 8 RET -- 9 NTRK -- 10 HER2 -- 11 KRAS -- 12 FGFR -- 13 Small Cell Lung Cancer -- 14 Conclusion -- References -- Epigenetic Events in Lung Cancer -- 1 Introduction -- 2 Classification of the Epigenetic Modifications -- 2.1 DNA Methylation -- 2.2 Regulators of the Chromatin Structure: Histone Modifiers -- 2.2.1 Histone Acetyltransferases -- 2.2.2 Histone Deacetylases 001476060 5058_ $$a2.2.3 Histone Methyltransferases -- 2.2.4 Histone Demethylases -- 2.3 Regulators of the Chromatin Structure: Chromatin Remodeling Complexes -- 3 Landscape of the Epigenetic Abnormalities in Lung Cancer -- 3.1 Aberrant DNA Methylation -- 3.2 Gene Abnormalities Affecting Chromatin Remodelers: The SWI/SNF Complex -- 3.3 Abnormalities in Histone Modifiers -- 4 Epigenetic-Based Therapeutic Strategies in Lung Cancer -- 4.1 DNA Methyltransferase Inhibitors -- 4.2 Histone Deacetylase Inhibitors -- 4.3 Other Epigenetic Inhibitors -- 5 Conclusions and Future Directions -- References 001476060 5058_ $$aPart II: Clinical Investigations -- Interventional Pulmonology -- 1 Introduction -- 2 Diagnostic Techniques -- 2.1 Autofluorescence Videobronchoscopy -- 2.2 Narrow-Band Imaging -- 2.3 Endobronchial Ultrasound -- 2.4 Recent Diagnostic Techniques in Interventional Pulmonology -- 3 Therapeutic Techniques -- 3.1 Techniques with Immediate Effect -- 3.1.1 Nd:YAG and Ho:YAG Laser Photoresection -- 3.1.2 Electrocautery -- 3.1.3 Argon Plasma Coagulation -- 3.2 Techniques with Delayed Effect -- References -- Pathology of Lung Cancer -- 1 Introduction -- 2 Adenocarcinoma -- 2.1 Background 001476060 5058_ $$a2.2 Major Adenocarcinoma Patterns -- 2.3 Adenocarcinoma Variants -- 2.4 Nonmucinous Adenocarcinoma Classification -- 2.5 Grading of Lung Adenocarcinoma -- 2.6 Staging Issues Associated with Adenocarcinoma -- 3 Squamous Cell Carcinoma -- 3.1 Background -- 3.2 Histology of Squamous Cell Carcinoma -- 3.3 Differentiation of Primary Squamous Cell Carcinoma of the Lung from Metastatic Squamous Cell Carcinoma -- 4 Adenosquamous Carcinoma -- 5 Pleomorphic Carcinoma -- 6 Neuroendocrine Neoplasms of the Lung -- 6.1 Background -- 6.2 Histology of Neuroendocrine Neoplasms 001476060 5058_ $$a6.3 Immunohistochemistry for Neuroendocrine Neoplasms -- 6.4 Ki-67 Proliferative Index for Pulmonary Neuroendocrine Neoplasms -- 7 Molecular Diagnostics in NSCLC and Triage of Limited Tissue Samples for Comprehensive Diagnosis -- 8 Pathology Assessment of Post-Neoadjuvant Resections for NSCLC -- References -- Role of Radiologic Imaging in Lung Cancer -- 1 Introduction, Technical Advances -- 2 Diagnosis of Lung Cancer/Solitary Pulmonary Nodule -- 3 T Staging/NSCLC -- 4 N Staging/NSCLC -- 5 M Staging/NSCLC -- 6 CT in Treatment Response Assessment and Follow-Up of NSCLC -- References 001476060 506__ $$aAccess limited to authorized users. 001476060 520__ $$aThis is the third, completely updated edition of a comprehensive book in which many of the worlds leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings in lung cancer and other intrathoracic malignancies. Lung cancer remains the major cancer killer in both sexes worldwide. It is so despite significant progress in recent decades in both diagnostic and treatment approaches. New biological and technological advances in this field are now faster incorporated in the overall decision-making process and are bringing fast and substantial improvements in both survivals and quality of life of lung cancer patients. Optimized patient-oriented approaches are reality of the third decade of this millennium and thoracic oncologists strive towards nothing but seamlessly delivering it in a continuous battle with lung cancer. The first three sections of the work cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer as well as other intrathoracic malignancies are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including stereotactic radiotherapy, and particle therapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer. This concise yet comprehensive book is an invaluable resource for radiation oncologists. 001476060 588__ $$aOnline resource; title from PDF title page (SpringerLink Ideas, viewed August 25, 2023). 001476060 650_0 $$aLungs$$xCancer$$xRadiotherapy. 001476060 650_0 $$aCancer$$xRadiotherapy. 001476060 650_0 $$aRadiotherapy. 001476060 650_0 $$aDiagnostic imaging. 001476060 650_6 $$aPoumons$$xCancer$$xRadiothérapie. 001476060 650_6 $$aCancer$$xRadiothérapie. 001476060 650_6 $$aRadiothérapie. 001476060 650_6 $$aImagerie pour le diagnostic. 001476060 655_0 $$aElectronic books. 001476060 7001_ $$aJeremić, Branislav. 001476060 77608 $$iPrint version:$$aJeremić, Branislav$$tAdvances in Radiation Oncology in Lung Cancer$$dCham : Springer International Publishing AG,c2023$$z9783031348464 001476060 830_0 $$aMedical radiology (Series) 001476060 852__ $$bebk 001476060 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-34847-1$$zOnline Access$$91397441.1 001476060 909CO $$ooai:library.usi.edu:1476060$$pGLOBAL_SET 001476060 980__ $$aBIB 001476060 980__ $$aEBOOK 001476060 982__ $$aEbook 001476060 983__ $$aOnline 001476060 994__ $$a92$$bISE