Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs) / Saurabh Gautam, Abhilash I. Chiramel, Roland Pach, editors.
Gautam, Saurabh, editor.; Chiramel, Abhilash I. editor.; Pach, Roland, editor.
2023
RM411
Available Online

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Title Bioprocess and analytics development for virus-based advanced therapeutics and medicinal products (ATMPs) / Saurabh Gautam, Abhilash I. Chiramel, Roland Pach, editors.
ISBN 9783031284892 (electronic bk.)
3031284895 (electronic bk.)
3031284887
9783031284885
DOI https://doi.org/10.1007/978-3-031-28489-2
Published Cham, Switzerland : Springer, 2023.
Language English
Description 1 online resource (xvi, 442 pages) : illustrations (some color)
Item Number 10.1007/978-3-031-28489-2 doi
Call Number RM411
Dewey Decimal Classification 615.7924
Summary This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called "magic bullet" (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed August 22, 2023).
Added Author Gautam, Saurabh, editor.
Chiramel, Abhilash I. editor.
Pach, Roland, editor.
Available in Other Form Bioprocess and Analytics Development for Virus-Based Advanced Therapeutics and Medicinal Products (ATMPs)
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Record Appears in Online Resources > Ebooks
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Chapter 1: Bioprocessing and analytical development for virus-based therapeutics
Chapter 2: Viral Vector Upstream Processing and Clarification
Chapter 3: Upstream processing of viral therapeutics: From host cell expansion to virus production
Chapter 4: Leveraging virus biology and host genetic conflicts for cell line development and engineering for virus-based therapeutics
Chapter 5: Overview of Current Downstream Processing for Modern Viral Vectors
Chapter 6: Filtration Principles and Techniques for Bioprocessing of Viral Vector–Based Therapeutics
Chapter 7: Chromatographic purification of viruses: State of the art and current trends
Chapter 8: Purifying Viral Vectors - A Review of Chromatography Solutions
Chapter 9: Particle analytics - Comparative approaches for analysis of viral vectors
Chapter 10: Phase-Appropriate Potency Assay Development for AAV-based Gene Therapy Products
Chapter 11: Quantification of virus infectivity – the key assay for the development of viral therapeutics
Chapter 12: Product-related impurities in therapeutic virus bioprocessing
Chapter 13: Process Analytical Technologies (PAT) and Quality by Design (QbD) for bioprocessing of virus-based therapeutics
Chapter 14: Methods and practical considerations in imaging viral therapeutics
Chapter 15: Application of NMR Spectroscopy in Viral Assembly Characterization
Chapter 16: Improved Production Strategies for Oncolytic Measles Viruses as a Therapeutic Cancer Treatment
Chapter 17: Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus Like Particles (VLPs)
Chapter 18: Oncolytic viruses and viral gene therapy vectors: Principles of safety.

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