Intro
Preface
Contents
Editor and Contributors
About the Editor
Contributors
Contributors to Figures
Native English Editors of Book
1: A Quick Glance at the Neuromuscular Disorders
What Is a Neuromuscular Disorder?
Where Do Neuromuscular Disorders Originate?
How Are Neuromuscular Disorders Classified?
Why Is the Differential Diagnosis of Neuromuscular Disorders Necessary?
Do Muscle and Nerve Biopsies Contribute to the Differential Diagnosis of Neuromuscular Disorders?

Does a Differential Diagnosis Contribute to the Treatment of Neuromuscular Disorders?
What Will the Future Management of Neuromuscular Disorders Be Like?
References
2: Understanding of the Muscle and Nerve Tissue
Embryologic Development of Muscle Tissue
Embryologic Development of Nerve Tissue
Histology of the Skeletal Muscle
Histology of Peripheral Nerves
Understanding Mitochondria
Understanding the Cell's Energy Production
References
3: The Procedure of Nerve Biopsy
References
4: The Procedure of Muscle Biopsy
Introduction
Indications

Biopsy Procedure
Open Biopsy
Needle Biopsy
Patient Preparation Before the Procedure
Shipping of the Specimen
Technical Issues
Complications
References
5: Preparation of Muscle and Nerve Biopsy
Preparation of Muscle Biopsy
Histochemical Stains and Reactions of Muscle Biopsy
Enzyme Stains and Reactions of Muscle Biopsy
Immune-Based Analyses Used for Muscle Biopsy
Preparation of Nerve Biopsy
Histochemical and Immunohistochemical Stains of Nerve Biopsy
Diagnostic Usefulness of Electron Microscopy for Muscle and Nerve Biopsies
References

6: How to Read a Muscle or a Nerve Biopsy?
How to Read a Muscle Biopsy?
How to Read a Nerve Biopsy?
References
7: Molecular Diagnostic Procedures and Genetics in Neuromuscular Disorders
Genetic Basis of Diseases
Molecular Genetic Diagnostic Methods and Bioinformatics Approaches
Molecular Genetic Basis of Neuromuscular Diseases
Dystrophinopathies
Myotonic Dystrophy Type 1 (DM1)
Facioscapulohumeral Muscular Dystrophy (FSHD)
Limb-Girdle Muscular Dystrophy (LGMD)
Congenital Myopathies (CM)
Nemaline Myopathy

Core Myopathy (Central Core and Multiminicore/Multicore)
Centronuclear Myopathy (Myotubular Myopathy/Autosomal Centronuclear Myopathy)
Congenital Fiber-Type Disproportionate Myopathy
Myosin Deposition Myopathy
Congenital Muscular Dystrophy (CMD)
Structural Protein Defects
Glycosylation Defects
Defects of Endoplasmic Reticulum Proteins
Defects of Nuclear Envelope Proteins
Spinal Muscular Atrophy (SMA)
Charcot-Marie-Tooth Disease (CMT)
References
8: Radiological Procedures Used in the Differential Diagnosis of Neuromuscular Disorders
Introduction
Radiological Modalities in Neuromuscular Imaging