Intro
Preface
Acknowledgments
Contents
About the Authors
1: Protein Networks in Human Disease
1.1 Introduction to Genetic Basis of Disease
1.2 Classical Protein Complexes in the Cell
1.3 Characterization of Disease-Related Mutations at Protein Interaction Interfaces
1.4 Role of Protein Interactions in Disease
1.5 Impact of Protein Interaction Networks on Analysis of Disease Genes: A Case Study
1.5.1 Potential Therapeutic Drug Targets in COVID-19
1.5.2 Drug Repurposing Strategy
1.6 Intrinsic Disorder-Based Human Diseases

1.7 PPIs in GPCR-Related Diseases
1.8 PPIs Related to Cataract Formation
1.8.1 Etiology of Cataract
1.9 PPIs Involved in Cystic Fibrosis
1.10 PPIs in Ubiquitin-Proteasome Pathway
1.11 PPIs in MODY (Maturity Onset Diabetes of the Young) Family
1.12 Conclusion
References
2: Protein-Protein Interactions in Cancer
2.1 Introduction to Cancer
2.2 Profiling PPIs of Single Cancer Cells
2.3 Building Cancer Cell Maps
2.4 OncoPPI Portal
2.5 PPIs Between Growth Factors/Chemokines and Their Receptors
2.6 PPIs for Cytoskeleton Dynamic Pathways

3.4.4 Parkin (PARK2)
3.4.5 Apolipoprotein E (APOE)
3.5 Amyotrophic Lateral Sclerosis (ALS)
3.5.1 TAR DNA-Binding Protein-43 (TDP-43)
3.5.2 Superoxide Dismutase-1 (SOD1)
3.5.3 Fused in Sarcoma (FUS)
3.6 Huntington Disease
3.6.1 Transcription Factors
3.6.2 Autophagy-Related Protein
3.6.3 Cell Division-Related Proteins
3.6.4 Trafficking Vesicle-Associated Proteins
3.7 Spinal Muscular Atrophy
3.7.1 Plastin 3 (PLS3)
3.7.2 Gemins
3.7.3 Profilins (PFN)
3.8 Frontotemporal Dementia (FTD)
3.8.1 Tau Protein
3.8.2 Progranulin