001476478 000__ 06413cam\\22006857a\4500
001476478 001__ 1476478
001476478 003__ OCoLC
001476478 005__ 20231003174423.0
001476478 006__ m\\\\\o\\d\\\\\\\\
001476478 007__ cr\un\nnnunnun
001476478 008__ 230904s2023\\\\sz\\\\\\o\\\\\001\0\eng\d
001476478 019__ $$a1396065781$$a1396907567
001476478 020__ $$a9783031365263$$q(electronic bk.)
001476478 020__ $$a3031365267$$q(electronic bk.)
001476478 020__ $$z3031365259
001476478 020__ $$z9783031365256
001476478 0247_ $$a10.1007/978-3-031-36526-3$$2doi
001476478 035__ $$aSP(OCoLC)1396060234
001476478 040__ $$aYDX$$beng$$cYDX$$dGW5XE$$dQGK$$dEBLCP
001476478 049__ $$aISEA
001476478 050_4 $$aRC374.C48
001476478 08204 $$a616.853061$$223/eng/20230914
001476478 24500 $$aPharmacoresistance in epilepsy:$$bfrom genes and molecules to promising therapies /$$cLuisa L. Rocha, Alberto Lazarowski, Esper A. Cavalheiro, editors.
001476478 250__ $$a2nd ed.
001476478 260__ $$aCham :$$bSpringer,$$c2023.
001476478 300__ $$a1 online resource
001476478 336__ $$atext$$btxt$$2rdacontent
001476478 337__ $$acomputer$$bc$$2rdamedia
001476478 338__ $$aonline resource$$bcr$$2rdacarrier
001476478 500__ $$aIncludes index.
001476478 5050_ $$aIntro -- Preface -- Contents -- Contributors -- Chapter 1: Why Study Drug-Resistant Epilepsy? -- References -- Chapter 2: Pharmacoresistance in Epilepsy -- 2.1 Epilepsy -- 2.2 Epilepsy as Stigma -- 2.3 Epilepsy and Pharmacoresistance -- 2.4 Epilepsy as Health Problem -- 2.5 Burden of Pharmacoresistant Epilepsy -- 2.6 Epilepsy Care -- 2.7 Conclusion -- References -- Chapter 3: Experimental Models for the Study of Drug-Resistant Epilepsy -- 3.1 Introduction -- 3.2 In Vitro Models -- 3.2.1 Cell Cultures -- 3.2.2 Brain Slices with Cortical Dysplasia Exposed to 4-Aminopyridine
001476478 5058_ $$a3.2.3 In Vitro Study of Brain Tissue from Patients with Drug-Resistant Epilepsy -- 3.3 In Vivo Models of Drug-Resistant Seizures -- 3.3.1 Caenorhabditis Elegans -- 3.3.2 Zebrafish -- 3.4 Induction of Drug-Resistant Seizures by Repeated Administration of Proconvulsant Drugs -- 3.5 Chemical Kindling and Drug Resistance -- 3.6 Electrical Kindling and Drug Resistance -- 3.7 Corneal Electric Kindling -- 3.8 Models of Drug-Resistant Epilepsy -- 3.8.1 Drug-Resistant Epilepsy Secondary to Status Epilepticus Due to Lithium-Pilocarpine -- 3.8.2 Kainic Acid and Drug-Resistant Epilepsy
001476478 5058_ $$a3.8.3 Models of Drug-Resistant Posttraumatic Epilepsy -- 3.8.4 Canines with Drug-Resistant Epilepsy -- 3.9 Models of Drug-Resistant Epilepsy Due to Genetic Alterations -- 3.10 Novel Approaches to Assess Drug-Resistant epilepsy in Animal Models -- 3.11 Epilepsy Therapy Screening Program: Advantages and Limitations for the Detection of Therapies for Drug-Resistant Epilepsy -- 3.12 Conclusions -- References -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- 4.1 Introduction -- 4.2 Emergence: Linking Multiple Hypotheses of DRE
001476478 5058_ $$a4.3 The Role of Comorbidities in DRE -- 4.4 Systems Biology: Dealing with the Multiple Mechanisms of DRE -- 4.5 The Advent of Systems Pharmacology for the Treatment of Epilepsy -- 4.6 Conclusion -- References -- Chapter 5: The Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- 5.1 Introduction -- 5.2 Different Types of HFO in Normal Brain and the Brain with Focal Epilepsy -- 5.3 Mechanisms Generating Normal and Pathological HFO and the Contributions of Inhibitory and Excitatory Cells -- 5.4 Fast Ripples as Biomarkers of Epileptogenic Tissue
001476478 5058_ $$a5.5 Proposed Roles of FR in Surgical Planning -- 5.6 Utilizing FR Graph Theoretical Metrics to Assess the Epileptogenic Network for Surgical Planning -- 5.7 Stimulation Therapy of the Epileptogenic Network -- 5.8 Summary -- References -- Chapter 6: Transporter Hypothesis in Pharmacoresistant Epilepsies: Is it at the Central or Peripheral Level? -- 6.1 Introduction -- 6.2 The Multidrug Resistance (MDR) Phenotype -- 6.3 Role of ABC-t in the "LADME System" as the Peripheral Mechanism of Drug Resistance in Epilepsy -- 6.4 ABC-t in the Central Mechanism of Drug-Resistant Epilepsy
001476478 506__ $$aAccess limited to authorized users.
001476478 520__ $$aThis new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
001476478 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 14, 2023).
001476478 650_0 $$aDrug resistance.
001476478 650_0 $$aEpilepsy$$xChemotherapy.
001476478 650_0 $$aEpilepsy$$xTreatment.
001476478 655_0 $$aElectronic books.
001476478 7001_ $$aRocha, Luisa.
001476478 7001_ $$aLazarowski, Alberto.
001476478 7001_ $$aCavalheiro, Esper A.
001476478 77608 $$iPrint version: $$z3031365259$$z9783031365256$$w(OCoLC)1381204797
001476478 852__ $$bebk
001476478 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-36526-3$$zOnline Access$$91397441.1
001476478 909CO $$ooai:library.usi.edu:1476478$$pGLOBAL_SET
001476478 980__ $$aBIB
001476478 980__ $$aEBOOK
001476478 982__ $$aEbook
001476478 983__ $$aOnline
001476478 994__ $$a92$$bISE