001476522 000__ 06062cam\\22007097a\4500 001476522 001__ 1476522 001476522 003__ OCoLC 001476522 005__ 20231003174425.0 001476522 006__ m\\\\\o\\d\\\\\\\\ 001476522 007__ cr\un\nnnunnun 001476522 008__ 230902s2023\\\\si\\\\\\ob\\\\000\0\eng\d 001476522 019__ $$a1395538906$$a1396869538 001476522 020__ $$a9789819928040$$q(electronic bk.) 001476522 020__ $$a9819928044$$q(electronic bk.) 001476522 020__ $$z9819928036 001476522 020__ $$z9789819928033 001476522 0247_ $$a10.1007/978-981-99-2804-0$$2doi 001476522 035__ $$aSP(OCoLC)1396064979 001476522 040__ $$aEBLCP$$beng$$cEBLCP$$dYDX$$dGW5XE$$dQGK 001476522 049__ $$aISEA 001476522 050_4 $$aTP983 001476522 08204 $$a668.550287$$223/eng/20230914 001476522 24500 $$aSkin 3-D models and cosmetics toxicity /$$cAditya Bhushan Pant, Ashish Dwivedi, Ratan Singh Ray, Anurag Tripathi, Atul Kumar Upadhyay, Shiv Poojan, editors. 001476522 260__ $$aSingapore :$$bSpringer,$$c2023. 001476522 300__ $$a1 online resource (266 p.) 001476522 336__ $$atext$$btxt$$2rdacontent 001476522 337__ $$acomputer$$bc$$2rdamedia 001476522 338__ $$aonline resource$$bcr$$2rdacarrier 001476522 500__ $$a4.3.4 Determining Barrier Performance of the Retained Skin Model 001476522 504__ $$aIncludes bibliographical references. 001476522 5050_ $$aIntro -- Preface -- About This Book -- Contents -- Editors and Contributors -- 1: Artificial Skin Models for Animal-Free Testing: 3D Skin Reconstruct Approach, a Journey in the Past Two Decades -- 1.1 Introduction -- 1.2 Approach Toward an Animal Alternative -- 1.3 Merits/Demerits of Elective Methods -- 1.4 Skin Equivalent: 3D Skin Model, a Valuable Alternative to Animal Tests -- 1.5 Skin Equivalents As Far -- 1.5.1 In Vitro Reconstituted Epidermis -- 1.5.2 Development of Full-Thickness Skin Equivalents (FTSE) -- 1.5.3 Most Recent Skin Equivalents 001476522 5058_ $$a1.6 Future Perspective: Next-Generation Skin Equivalents, a More Advanced Way Ahead! -- 1.7 Conclusion -- References -- Uncategorized References -- 2: Fabrication of Ready-to-Use Ex Vivo Human Skin Models for Chemical Testing: Current Status and Challenges -- 2.1 Part 1: Introduction -- 2.1.1 Skin Appendages -- 2.2 Part 2: Reconstructed Human Epidermis (RHE) and Full-Thickness Skin (FTS) Models -- 2.2.1 Reconstructed Human Epidermis (RHE) -- 2.2.2 Full-Thickness Skin (FTS) -- 2.2.3 Future Developments of FTS and RHE Models -- 2.3 Part 3: Bioprinting of Skin Constructs 001476522 5058_ $$a2.3.1 Biomaterials for Skin Bioinks -- 2.3.2 Advances in Skin Bioprinting -- 2.3.3 Bioprinting Limitations and New Prospective -- 2.4 Part 4: Micro-Tissue Equivalents (Organoids) Models -- 2.4.1 Organoid Models of Disease -- 2.5 Part 5: Chemical Irritation, Corrosion, and Sensitization Testing Using Skin Organoids -- 2.6 Part 6: Summary and Conclusions -- References -- 3: Human Skin Reconstructs Model Systems in Mechanistic Research, Safety, and Efficacy Studies of Cosmetics: Pros and Cons -- 3.1 Introduction -- 3.2 3D Skin Models in the Dermatological Studies 001476522 5058_ $$a3.3 Microfluidics: 3D Skin-on-a-Chip Platform -- 3.4 Ex Vivo Skin Explant -- 3.5 Advantages of 3D Skin or Ex Vivo Skin Explants -- 3.6 Limitations and Other Perspectives of 3D Skin or Ex Vivo Skin Explants -- References -- 4: Skin-on-a-Chip Microfluidic Devices: Production, Verification, and Uses in Cosmetic Toxicology -- 4.1 Introduction -- 4.2 Production of Skin-on-a-Chip Devices -- 4.2.1 Sourcing and Production of Skin Models for Skin-on-a-Chip Devices -- 4.2.2 Fabrication Methodologies of the Housing Units of Skin-on-a-Chip Devices 001476522 5058_ $$a4.2.3 Material Selection for Fabrication of Skin-on-a-Chip Housing Plates -- 4.2.4 Design of the Nutrient Support System Within the Skin-on-a-Chip Device -- 4.2.5 Biosensor Integration into the Skin-on-a-Chip Device -- 4.3 Verification of Skin Structure and Function Within the Skin-on-a-Chip Device -- 4.3.1 Histological and Immunohistological Examination of Skin Model Structure -- 4.3.2 Determining Cell Viability of the Retained Skin Model -- 4.3.3 Accessing the Flow Rate and Perfusion of the Retained Skin Model by the Vascular/Microfluidic System 001476522 506__ $$aAccess limited to authorized users. 001476522 520__ $$aEfforts are being made by research organizations and cosmetic industries worldwide to develop more precise and targeted 3D models that mimic humans for testing cosmetic and personal health care product ingredients, following a complete ban on animal testing. This book includes several subtopics dedicated to the progress made, challenges faced, roadblocks encountered, and future prospects in the development and validation of 3D models for testing these products. The book consist of an editorial and 14 themed chapters that will showcase the significant progress made so far, challenges encountered, and future prospects in the development of 3D reconstruct models. 001476522 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 14, 2023). 001476522 650_0 $$aCosmetics$$xTesting. 001476522 650_0 $$aSkin. 001476522 655_0 $$aElectronic books. 001476522 7001_ $$aPant, Aditya Bhushan. 001476522 7001_ $$aDwivedi, Ashish. 001476522 7001_ $$aRay, Ratan Singh. 001476522 7001_ $$aTripathi, Anurag. 001476522 7001_ $$aUpadhyay, Atul Kumar. 001476522 7001_ $$aPoojan, Shiv. 001476522 77608 $$iPrint version:$$aPant, Aditya Bhushan$$tSkin 3-D Models and Cosmetics Toxicity$$dSingapore : Springer,c2023$$z9789819928033 001476522 852__ $$bebk 001476522 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-981-99-2804-0$$zOnline Access$$91397441.1 001476522 909CO $$ooai:library.usi.edu:1476522$$pGLOBAL_SET 001476522 980__ $$aBIB 001476522 980__ $$aEBOOK 001476522 982__ $$aEbook 001476522 983__ $$aOnline 001476522 994__ $$a92$$bISE