001476525 000__ 06391cam\\2200661\i\4500 001476525 001__ 1476525 001476525 003__ OCoLC 001476525 005__ 20231003174425.0 001476525 006__ m\\\\\o\\d\\\\\\\\ 001476525 007__ cr\un\nnnunnun 001476525 008__ 230902s2023\\\\sz\a\\\\ob\\\\001\0\eng\d 001476525 019__ $$a1395947164$$a1396911682$$a1397020370 001476525 020__ $$a9783031337505$$q(electronic bk.) 001476525 020__ $$a3031337506$$q(electronic bk.) 001476525 020__ $$z3031337492 001476525 020__ $$z9783031337499 001476525 0247_ $$a10.1007/978-3-031-33750-5$$2doi 001476525 035__ $$aSP(OCoLC)1396065852 001476525 040__ $$aEBLCP$$beng$$erda$$cEBLCP$$dYDX$$dGW5XE$$dN$T$$dEBLCP$$dOCLCO 001476525 049__ $$aISEA 001476525 050_4 $$aRC268.25 001476525 08204 $$a616.994$$223/eng/20230914 001476525 24500 $$aEnvironmental oncology :$$btheory and impact /$$ceditor, Eric H. Bernicker. 001476525 264_1 $$aCham :$$bSpringer,$$c2023. 001476525 300__ $$a1 online resource. 001476525 336__ $$atext$$btxt$$2rdacontent 001476525 337__ $$acomputer$$bc$$2rdamedia 001476525 338__ $$aonline resource$$bcr$$2rdacarrier 001476525 504__ $$aIncludes bibliographical references and index. 001476525 5050_ $$a1: Molecular Mechanisms of Environmental Oncogenesis -- Overview -- Cancer Etiology -- Genetic Causes of Cancer -- Environmental Causes of Cancer -- Lifestyle and Cancer -- Smoking -- Alcohol -- Diet -- Obesity -- Physical Activity -- Infectious Agents -- Environmental and Lifestyle Influences by Cancer Type -- Concluding Remarks -- References -- 2: Air Pollution and Cancer -- Sources of Air Pollution -- Biology of Interaction Between Particles and the Respiratory Epithelium -- Respiratory Epithelium -- Barrier Dysfunction -- Mucociliary Dysfunction 001476525 5058_ $$aImmune-Mediated Alterations in Airway Epithelial Barrier Function upon Exposure to Air Pollutants -- Alveolar Macrophages -- Air Pollution and Cancer Development -- Air Pollution as Complicating Factor in Establish Cancer patient's Care -- Air Pollution and Other Non-cancerous Illnesses -- Summary and Call to Action -- References -- 3: Leaving No Stone Unturned: Unraveling the Path to Maximizing the Potential for Discovery of Novel Antineoplastics -- Introduction -- Vinca Alkaloids -- Discovery and Origin -- Pharmacology -- Vinblastine -- Vincristine -- Vinorelbine -- Clinical Use -- Taxanes 001476525 5058_ $$aDiscovery and Origin -- Pharmacology -- Paclitaxel -- Docetaxel -- Cabazitaxel -- Clinical Use and Impact -- Camptothecin Derivatives -- Discovery and Origin -- Pharmacology -- Topotecan -- Irinotecan -- Clinical Use and Impact -- Epipodophyllotoxins -- Discovery and Origin -- Pharmacology -- Etoposide -- Teniposide -- Clinical Use and Impact -- Potential Impact of Deforestation on Cancer Drug Discovery -- References -- Part II: Food, Lifestyle and Cancer -- 4: Meat and Alcohol Consumption: Diet and Lifestyle Choice and Cancer -- Introduction -- Meat Consumption and Cost 001476525 5058_ $$aThe Role of Heme Iron in Colon Cancer -- Gut Microbiome and Colon Cancer -- Immunotherapy and Colorectal Cancer -- Societal Costs and Colorectal Cancer -- Alcohol Intake and Cancer Risk -- Alcohol and Breast Cancer -- Alcohol and Head and Neck Cancer -- Alcohol and Upper and Lower GI Cancer -- Conclusion -- References -- 5: Tobacco, Second-Hand Smoke and Cancer -- Introduction -- Tobacco Smoking and Second-Hand Smoke -- Smoke-Induced Oxidative Stress in the Pathogenesis of COPD -- Oxidative Stress-Induced Damage in COPD -- Mitochondrial Dysfunction in COPD -- Inflammation in COPD 001476525 5058_ $$aThe Relationship Between COPD and Lung Cancer -- Oxidative Stress-Induced DNA Damage Links COPD to Lung Cancer -- Mitochondrial Dysfunction Links COPD to Lung Cancer -- Inflammation Links COPD to Lung Cancer -- Epigenetics Link COPD to Lung Cancer -- Smoking and the Management of Cancer -- Conclusions -- References -- 6: Sun Exposure and Skin Cancer -- Foreword -- Brief History and Evidence for Climate Change -- Complex Mechanisms of the Earth System Model -- How Climate Change Is Studied -- Climate Change Predictions and Models for the Current Century -- The Mechanism of UV Radiation-Related Cutaneous Carcinogenesis 001476525 506__ $$aAccess limited to authorized users. 001476525 520__ $$aThis book covers the wide range of malignant illness and where they intersect with environmental factors. Chapters explore the importance of acknowledging and dealing with the societal implications of anthropogenic climate change, a wider appreciation of the many ways that human industry and activity is changing the environment and contributing to human disease is imperative. In addition to how particular exposures relate to certain malignancies, the book explores historical events that led to the development of cancers in order to help policy makers and patient advocates understand where we have been when considering future initiatives. It also discusses the disparities involved in environmental toxin exposure and look at these cancers in light of the need to reduce cancer disparities. Given the ongoing ecological crisis from climate change and expanding human population and industrialization, this book examines pollution and ecological change to impacts and where human disease can be prevented. 001476525 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 14, 2023). 001476525 650_0 $$aCancer$$xEnvironmental aspects. 001476525 650_0 $$aEnvironmentally induced diseases. 001476525 650_6 $$aCancer$$xAspect de l'environnement. 001476525 650_6 $$aMaladies de l'environnement. 001476525 655_0 $$aElectronic books. 001476525 7001_ $$aBernicker, Eric H. 001476525 77608 $$iPrint version:$$aBernicker, Eric H.$$tEnvironmental Oncology$$dCham : Springer International Publishing AG,c2023$$z9783031337499 001476525 852__ $$bebk 001476525 85640 $$3Springer Nature$$uhttps://univsouthin.idm.oclc.org/login?url=https://link.springer.com/10.1007/978-3-031-33750-5$$zOnline Access$$91397441.1 001476525 909CO $$ooai:library.usi.edu:1476525$$pGLOBAL_SET 001476525 980__ $$aBIB 001476525 980__ $$aEBOOK 001476525 982__ $$aEbook 001476525 983__ $$aOnline 001476525 994__ $$a92$$bISE