Intro
Preface
Preface to the Second Edition
Preface to the First Edition
Contents
Contributors
1: Overview of the Development of the Human Brain and Spinal Cord
1.1 Introduction
1.2 Major Stages in the Development of the Human Brain and Spinal Cord
1.3 The First Three Weeks of Development
1.3.1 Implantation
1.3.2 Gastrulation
1.3.3 Folding of the Embryo
1.4 Neurulation
1.5 Development of the Spinal Cord
1.6 Pattern Formation of the Brain
1.7 Early Development of the Brain
1.7.1 Imaging of the Embryonic Brain
1.7.2 Neuromeres

1.7.3 The Ganglionic Eminences
1.8 Foetal Development of the Brain
1.8.1 The Cerebellum
1.8.2 The Cerebral Cortex
1.8.3 Cerebral Commissures
1.8.4 Imaging of the Foetal Brain
1.9 Development of the Meninges and Choroid Plexuses
1.10 Development of the Blood Supply of the Brain
1.11 Development of Fibre Tracts and Their Myelination
1.11.1 Development of Fibre Tracts
1.11.2 Development of Myelination
1.11.3 Prenatal Motor Behaviour
1.12 The Foetal Connectome
References
2: Mechanisms of Development
2.1 Introduction
2.2 Neural Induction

2.2.1 The Spemann-Mangold Organizer
2.2.2 The Molecular Basis of Neural Induction
2.2.3 Polarity and the Establishment of the Neuraxis
2.2.4 Neural Induction in Amniote Embryos
2.2.5 Specific Pathways for Head Induction
2.3 Cell Lineage Studies and Fate Mapping
2.4 Pattern Formation
2.4.1 Regionalization of the Forebrain
2.4.2 The Intrathalamic Limiting Zone
2.4.3 The Midbrain-Hindbrain Boundary Organizer
2.4.4 Segmentation of the Hindbrain
2.5 Specification of Cell Fate
2.5.1 Specification of Cell Fate in the Spinal Cord

2.5.2 Specification of Cell Fate in the Hindbrain
2.5.3 Specification of Cell Fate in the Midbrain
2.5.4 Specification of Cell Fate in the Diencephalon
2.5.5 Specification of Cell Fate in the Hypothalamus
2.5.6 Specification of Cell Fate in the Telencephalon
2.5.7 The Transcriptomic Approach to the Developing Central Nervous System
2.6 Neurogenesis, Gliogenesis and Migration
2.6.1 Neurogenesis: Primary and Secondary Proliferative Compartments
2.6.2 Gliogenesis
2.6.3 Migration
2.7 Axon Outgrowth and Guidance
2.7.1 Pioneer Fibres

2.7.2 The Guidance of Axons to Their Targets
2.7.3 Axon Guidance at Choice Points
2.7.4 Commissure Formation
2.7.5 Formation of Thalamocortical and Corticofugal Projections
2.7.6 Formation of Topographic Maps
2.7.7 Genetic Approaches of Neural Circuits in Mice
2.7.7.1 Molecular Odorant Map
2.7.7.2 Molecular Retinotopic Map
2.7.7.3 Molecular Somatosensory Map
2.7.7.4 Molecular Tonotopic Map
2.7.7.5 Molecular Taste Maps
2.7.7.6 Molecular Vestibular Maps
2.7.8 Human Disorders of Axon Guidance
2.8 Programmed Cell Death
References